Ebola virus disease: An emerging and re-emerging viral threat

Manuel Rojas, Diana M. Monsalve, Yovana Pacheco, Yeny Acosta-Ampudia, Carolina Ramírez-Santana, Aftab A. Ansari, M. Eric Gershwin, Juan Manuel Anaya

Research output: Contribution to journalReview article

Abstract

The genus Ebolavirus from the family Filoviridae is composed of five species including Sudan ebolavirus, Reston ebolavirus, Bundibugyo ebolavirus, Taï Forest ebolavirus, and Ebola virus (previously known as Zaire ebolavirus). These viruses have a large non-segmented, negative-strand RNA of approximately 19 kb that encodes for glycoproteins (i.e., GP, sGP, ssGP), nucleoproteins, virion proteins (i.e., VP 24, 30,40) and an RNA dependent RNA polymerase. These viruses have become a global health concern because of mortality, their rapid dissemination, new outbreaks in West-Africa, and the emergence of a new condition known as “Post-Ebola virus disease syndrome” that resembles inflammatory and autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus and spondyloarthritis with uveitis. However, there are many gaps in the understanding of the mechanisms that may induce the development of such autoimmune-like syndromes. Some of these mechanisms may include a high formation of neutrophil extracellular traps, an uncontrolled “cytokine storm”, and the possible formation of auto-antibodies. The likely appearance of autoimmune phenomena in Ebola survivors suppose a new challenge in the management and control of this disease and opens a new field of research in a special subgroup of patients. Herein, the molecular biology, pathogenesis, clinical manifestations, and treatment of Ebola virus disease are reviewed and some strategies for control of disease are discussed.

Original languageEnglish (US)
Article number102375
JournalJournal of autoimmunity
Volume106
DOIs
StatePublished - Jan 2020

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Ebola Hemorrhagic Fever
Ebolavirus
Filoviridae
Viruses
Democratic Republic of the Congo
RNA Replicase
Sudan
Nucleoproteins
Western Africa
Uveitis
Disease Management
Virion
Systemic Lupus Erythematosus
Antibody Formation
Disease Outbreaks
Survivors
Molecular Biology
Rheumatoid Arthritis
Glycoproteins
RNA

Keywords

  • Ebola virus
  • Ebola virus disease
  • Post-Ebola virus disease syndrome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Rojas, M., Monsalve, D. M., Pacheco, Y., Acosta-Ampudia, Y., Ramírez-Santana, C., Ansari, A. A., ... Anaya, J. M. (2020). Ebola virus disease: An emerging and re-emerging viral threat. Journal of autoimmunity, 106, [102375]. https://doi.org/10.1016/j.jaut.2019.102375

Ebola virus disease : An emerging and re-emerging viral threat. / Rojas, Manuel; Monsalve, Diana M.; Pacheco, Yovana; Acosta-Ampudia, Yeny; Ramírez-Santana, Carolina; Ansari, Aftab A.; Gershwin, M. Eric; Anaya, Juan Manuel.

In: Journal of autoimmunity, Vol. 106, 102375, 01.2020.

Research output: Contribution to journalReview article

Rojas, M, Monsalve, DM, Pacheco, Y, Acosta-Ampudia, Y, Ramírez-Santana, C, Ansari, AA, Gershwin, ME & Anaya, JM 2020, 'Ebola virus disease: An emerging and re-emerging viral threat', Journal of autoimmunity, vol. 106, 102375. https://doi.org/10.1016/j.jaut.2019.102375
Rojas M, Monsalve DM, Pacheco Y, Acosta-Ampudia Y, Ramírez-Santana C, Ansari AA et al. Ebola virus disease: An emerging and re-emerging viral threat. Journal of autoimmunity. 2020 Jan;106. 102375. https://doi.org/10.1016/j.jaut.2019.102375
Rojas, Manuel ; Monsalve, Diana M. ; Pacheco, Yovana ; Acosta-Ampudia, Yeny ; Ramírez-Santana, Carolina ; Ansari, Aftab A. ; Gershwin, M. Eric ; Anaya, Juan Manuel. / Ebola virus disease : An emerging and re-emerging viral threat. In: Journal of autoimmunity. 2020 ; Vol. 106.
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