Early postoperative results of Descemet’s stripping endothelial keratoplasty in six dogs with corneal endothelial dystrophy

Gladys Boo, Cameron J.G. Whittaker, Kelly A. Caruso, Gregory Moloney, Evelyn Hall, Rajnesh Devasahayam, Sara M Thomasy, Jeffrey S. Smith

Research output: Contribution to journalArticle

Abstract

Objective: To describe and assess the clinical outcome and intraoperative and postoperative complications of Descemet's stripping endothelial keratoplasty (DSEK) in the treatment of canine corneal endothelial dystrophy. Animals Studied: Six dogs (six eyes) diagnosed with progressive corneal edema resulting from abnormal dystrophic endothelial cells underwent Descemet's stripping endothelial keratoplasty. Procedures: Six patients underwent Descemet's stripping endothelial keratoplasty (DSEK). The patients were examined preoperatively and postoperatively at 24 hours, 7 days, 1, 2, and 3 months after surgery. Corneal edema and ultrasonic pachymetry were evaluated preoperatively and postoperatively. The positions of DSEK grafts were evaluated 3 months after surgery using optical coherence tomography. Intraoperative and postoperative complications were noted. Results: The degree of corneal edema and corneal thickness improved postoperatively in all the patients (n = 6). Fibrin was encountered intraoperatively in one out of the six eyes (1/6) and postoperatively in two out of the six eyes (2/6). One out of the six DSEK grafts was partially scrolled (1/6). Secondary ocular hypertension was observed in one out of the six eyes (1/6). Corneal vascularization was encountered in four out of six patients (4/6). Conclusions: Descemet's stripping endothelial keratoplasty is an effective surgical treatment option for corneal endothelial dystrophy in dogs. Corneal edema resolved and corneal thickness reduced significantly. The early postoperative results are encouraging. Further investigation is warranted to document any long-term complications and to study the longevity of the transplanted grafts.

Original languageEnglish (US)
JournalVeterinary Ophthalmology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Descemet Stripping Endothelial Keratoplasty
Corneal Edema
eyes
edema
Dogs
dogs
postoperative complications
Intraoperative Complications
Transplants
surgery
fibrin
tomography
Ocular Hypertension
hypertension
endothelial cells
Optical Coherence Tomography
Fibrin
ultrasonics
Ultrasonics
Canidae

Keywords

  • corneal endothelial dystrophy
  • Descemet’s stripping endothelial keratoplasty
  • dogs
  • pachymetry
  • pseudophakic bullous keratopathy

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Early postoperative results of Descemet’s stripping endothelial keratoplasty in six dogs with corneal endothelial dystrophy. / Boo, Gladys; Whittaker, Cameron J.G.; Caruso, Kelly A.; Moloney, Gregory; Hall, Evelyn; Devasahayam, Rajnesh; Thomasy, Sara M; Smith, Jeffrey S.

In: Veterinary Ophthalmology, 01.01.2019.

Research output: Contribution to journalArticle

Boo, Gladys ; Whittaker, Cameron J.G. ; Caruso, Kelly A. ; Moloney, Gregory ; Hall, Evelyn ; Devasahayam, Rajnesh ; Thomasy, Sara M ; Smith, Jeffrey S. / Early postoperative results of Descemet’s stripping endothelial keratoplasty in six dogs with corneal endothelial dystrophy. In: Veterinary Ophthalmology. 2019.
@article{1fa4ae6ae03b4107920e696e2498333b,
title = "Early postoperative results of Descemet’s stripping endothelial keratoplasty in six dogs with corneal endothelial dystrophy",
abstract = "Objective: To describe and assess the clinical outcome and intraoperative and postoperative complications of Descemet's stripping endothelial keratoplasty (DSEK) in the treatment of canine corneal endothelial dystrophy. Animals Studied: Six dogs (six eyes) diagnosed with progressive corneal edema resulting from abnormal dystrophic endothelial cells underwent Descemet's stripping endothelial keratoplasty. Procedures: Six patients underwent Descemet's stripping endothelial keratoplasty (DSEK). The patients were examined preoperatively and postoperatively at 24 hours, 7 days, 1, 2, and 3 months after surgery. Corneal edema and ultrasonic pachymetry were evaluated preoperatively and postoperatively. The positions of DSEK grafts were evaluated 3 months after surgery using optical coherence tomography. Intraoperative and postoperative complications were noted. Results: The degree of corneal edema and corneal thickness improved postoperatively in all the patients (n = 6). Fibrin was encountered intraoperatively in one out of the six eyes (1/6) and postoperatively in two out of the six eyes (2/6). One out of the six DSEK grafts was partially scrolled (1/6). Secondary ocular hypertension was observed in one out of the six eyes (1/6). Corneal vascularization was encountered in four out of six patients (4/6). Conclusions: Descemet's stripping endothelial keratoplasty is an effective surgical treatment option for corneal endothelial dystrophy in dogs. Corneal edema resolved and corneal thickness reduced significantly. The early postoperative results are encouraging. Further investigation is warranted to document any long-term complications and to study the longevity of the transplanted grafts.",
keywords = "corneal endothelial dystrophy, Descemet’s stripping endothelial keratoplasty, dogs, pachymetry, pseudophakic bullous keratopathy",
author = "Gladys Boo and Whittaker, {Cameron J.G.} and Caruso, {Kelly A.} and Gregory Moloney and Evelyn Hall and Rajnesh Devasahayam and Thomasy, {Sara M} and Smith, {Jeffrey S.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/vop.12666",
language = "English (US)",
journal = "Veterinary Ophthalmology",
issn = "1463-5216",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Early postoperative results of Descemet’s stripping endothelial keratoplasty in six dogs with corneal endothelial dystrophy

AU - Boo, Gladys

AU - Whittaker, Cameron J.G.

AU - Caruso, Kelly A.

AU - Moloney, Gregory

AU - Hall, Evelyn

AU - Devasahayam, Rajnesh

AU - Thomasy, Sara M

AU - Smith, Jeffrey S.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: To describe and assess the clinical outcome and intraoperative and postoperative complications of Descemet's stripping endothelial keratoplasty (DSEK) in the treatment of canine corneal endothelial dystrophy. Animals Studied: Six dogs (six eyes) diagnosed with progressive corneal edema resulting from abnormal dystrophic endothelial cells underwent Descemet's stripping endothelial keratoplasty. Procedures: Six patients underwent Descemet's stripping endothelial keratoplasty (DSEK). The patients were examined preoperatively and postoperatively at 24 hours, 7 days, 1, 2, and 3 months after surgery. Corneal edema and ultrasonic pachymetry were evaluated preoperatively and postoperatively. The positions of DSEK grafts were evaluated 3 months after surgery using optical coherence tomography. Intraoperative and postoperative complications were noted. Results: The degree of corneal edema and corneal thickness improved postoperatively in all the patients (n = 6). Fibrin was encountered intraoperatively in one out of the six eyes (1/6) and postoperatively in two out of the six eyes (2/6). One out of the six DSEK grafts was partially scrolled (1/6). Secondary ocular hypertension was observed in one out of the six eyes (1/6). Corneal vascularization was encountered in four out of six patients (4/6). Conclusions: Descemet's stripping endothelial keratoplasty is an effective surgical treatment option for corneal endothelial dystrophy in dogs. Corneal edema resolved and corneal thickness reduced significantly. The early postoperative results are encouraging. Further investigation is warranted to document any long-term complications and to study the longevity of the transplanted grafts.

AB - Objective: To describe and assess the clinical outcome and intraoperative and postoperative complications of Descemet's stripping endothelial keratoplasty (DSEK) in the treatment of canine corneal endothelial dystrophy. Animals Studied: Six dogs (six eyes) diagnosed with progressive corneal edema resulting from abnormal dystrophic endothelial cells underwent Descemet's stripping endothelial keratoplasty. Procedures: Six patients underwent Descemet's stripping endothelial keratoplasty (DSEK). The patients were examined preoperatively and postoperatively at 24 hours, 7 days, 1, 2, and 3 months after surgery. Corneal edema and ultrasonic pachymetry were evaluated preoperatively and postoperatively. The positions of DSEK grafts were evaluated 3 months after surgery using optical coherence tomography. Intraoperative and postoperative complications were noted. Results: The degree of corneal edema and corneal thickness improved postoperatively in all the patients (n = 6). Fibrin was encountered intraoperatively in one out of the six eyes (1/6) and postoperatively in two out of the six eyes (2/6). One out of the six DSEK grafts was partially scrolled (1/6). Secondary ocular hypertension was observed in one out of the six eyes (1/6). Corneal vascularization was encountered in four out of six patients (4/6). Conclusions: Descemet's stripping endothelial keratoplasty is an effective surgical treatment option for corneal endothelial dystrophy in dogs. Corneal edema resolved and corneal thickness reduced significantly. The early postoperative results are encouraging. Further investigation is warranted to document any long-term complications and to study the longevity of the transplanted grafts.

KW - corneal endothelial dystrophy

KW - Descemet’s stripping endothelial keratoplasty

KW - dogs

KW - pachymetry

KW - pseudophakic bullous keratopathy

UR - http://www.scopus.com/inward/record.url?scp=85063140658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063140658&partnerID=8YFLogxK

U2 - 10.1111/vop.12666

DO - 10.1111/vop.12666

M3 - Article

JO - Veterinary Ophthalmology

JF - Veterinary Ophthalmology

SN - 1463-5216

ER -