Early menarche and childhood adversities in a nationally representative sample

Kimberly L. Henrichs, Heather L. McCauley, Elizabeth Miller, Dennis M Styne, Naomi Saito, Joshua Breslau

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Epidemiological evidence suggests that early menarche, defined as onset of menses at age 11 or earlier, has increased in prevalence in recent birth cohorts and is associated with multiple poor medical and mental health outcomes in adulthood. There is evidence that childhood adversities occurring prior to menarche contribute to early menarche.Methods: Data collected in face-to-face interviews with a nationally representative sample of women age 18 and over (N = 3288), as part of the National Comorbidity Survey-Replication, were analyzed. Associations between pre-menarchal childhood adversities and menarche at age 11 or earlier were estimated in discrete time survival models with statistical adjustment for age at interview, ethnicity, and body mass index. Adversities investigated included physical abuse, sexual abuse, neglect, biological father absence from the home, other parent loss, parent mental illness, parent substance abuse, parent criminality, inter-parental violence, serious physical illness in childhood, and family economic adversity.Results: Mean age at menarche varied across decadal birth cohorts (χ2 (4) = 21.41, p < .001) ranging from a high of 12.9 years in the oldest cohort (age 59 or older at the time of interview) to a low of 12.4 in the second youngest cohort (age 28-37). Childhood adversities were also more common in younger than older cohorts. Of the 11 childhood adversities, 5 were associated with menarche at age 11 or earlier, with OR of 1.3 or greater. Each of these five adversities is associated with a 26% increase in the odds of early menarche (OR = 1.26, 95% CI 1.14-1.39). The relationship between childhood sexual abuse and early menarche was sustained after adjustment for co-occurring adversities. (OR = 1.77, 95% CI 1.21-2.6).Conclusions: Evidence from this study is consistent with hypothesized physiological effects of early childhood family environment on endocrine development. Childhood sexual abuse is the adversity most strongly associated with early menarche. However, because of the complex way that childhood adversities cluster within families, the more generalized influence of highly dysfunctional family environments cannot be ruled out.

Original languageEnglish (US)
Article number14
JournalInternational Journal of Pediatric Endocrinology
Volume2014
Issue number1
DOIs
StatePublished - Jul 15 2014

Fingerprint

Menarche
Sex Offenses
Interviews
Parturition
Menstruation
Statistical Models
Age of Onset
Fathers
Substance-Related Disorders
Comorbidity
Mental Health
Body Mass Index
Economics
Survival

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Early menarche and childhood adversities in a nationally representative sample. / Henrichs, Kimberly L.; McCauley, Heather L.; Miller, Elizabeth; Styne, Dennis M; Saito, Naomi; Breslau, Joshua.

In: International Journal of Pediatric Endocrinology, Vol. 2014, No. 1, 14, 15.07.2014.

Research output: Contribution to journalArticle

Henrichs, Kimberly L. ; McCauley, Heather L. ; Miller, Elizabeth ; Styne, Dennis M ; Saito, Naomi ; Breslau, Joshua. / Early menarche and childhood adversities in a nationally representative sample. In: International Journal of Pediatric Endocrinology. 2014 ; Vol. 2014, No. 1.
@article{fe68ab1cb7a54cfdab60514f26d8c8fa,
title = "Early menarche and childhood adversities in a nationally representative sample",
abstract = "Background: Epidemiological evidence suggests that early menarche, defined as onset of menses at age 11 or earlier, has increased in prevalence in recent birth cohorts and is associated with multiple poor medical and mental health outcomes in adulthood. There is evidence that childhood adversities occurring prior to menarche contribute to early menarche.Methods: Data collected in face-to-face interviews with a nationally representative sample of women age 18 and over (N = 3288), as part of the National Comorbidity Survey-Replication, were analyzed. Associations between pre-menarchal childhood adversities and menarche at age 11 or earlier were estimated in discrete time survival models with statistical adjustment for age at interview, ethnicity, and body mass index. Adversities investigated included physical abuse, sexual abuse, neglect, biological father absence from the home, other parent loss, parent mental illness, parent substance abuse, parent criminality, inter-parental violence, serious physical illness in childhood, and family economic adversity.Results: Mean age at menarche varied across decadal birth cohorts (χ2 (4) = 21.41, p < .001) ranging from a high of 12.9 years in the oldest cohort (age 59 or older at the time of interview) to a low of 12.4 in the second youngest cohort (age 28-37). Childhood adversities were also more common in younger than older cohorts. Of the 11 childhood adversities, 5 were associated with menarche at age 11 or earlier, with OR of 1.3 or greater. Each of these five adversities is associated with a 26{\%} increase in the odds of early menarche (OR = 1.26, 95{\%} CI 1.14-1.39). The relationship between childhood sexual abuse and early menarche was sustained after adjustment for co-occurring adversities. (OR = 1.77, 95{\%} CI 1.21-2.6).Conclusions: Evidence from this study is consistent with hypothesized physiological effects of early childhood family environment on endocrine development. Childhood sexual abuse is the adversity most strongly associated with early menarche. However, because of the complex way that childhood adversities cluster within families, the more generalized influence of highly dysfunctional family environments cannot be ruled out.",
author = "Henrichs, {Kimberly L.} and McCauley, {Heather L.} and Elizabeth Miller and Styne, {Dennis M} and Naomi Saito and Joshua Breslau",
year = "2014",
month = "7",
day = "15",
doi = "10.1186/1687-9856-2014-14",
language = "English (US)",
volume = "2014",
journal = "International Journal of Pediatric Endocrinology",
issn = "1687-9848",
publisher = "BioMed Central Ltd.",
number = "1",

}

TY - JOUR

T1 - Early menarche and childhood adversities in a nationally representative sample

AU - Henrichs, Kimberly L.

AU - McCauley, Heather L.

AU - Miller, Elizabeth

AU - Styne, Dennis M

AU - Saito, Naomi

AU - Breslau, Joshua

PY - 2014/7/15

Y1 - 2014/7/15

N2 - Background: Epidemiological evidence suggests that early menarche, defined as onset of menses at age 11 or earlier, has increased in prevalence in recent birth cohorts and is associated with multiple poor medical and mental health outcomes in adulthood. There is evidence that childhood adversities occurring prior to menarche contribute to early menarche.Methods: Data collected in face-to-face interviews with a nationally representative sample of women age 18 and over (N = 3288), as part of the National Comorbidity Survey-Replication, were analyzed. Associations between pre-menarchal childhood adversities and menarche at age 11 or earlier were estimated in discrete time survival models with statistical adjustment for age at interview, ethnicity, and body mass index. Adversities investigated included physical abuse, sexual abuse, neglect, biological father absence from the home, other parent loss, parent mental illness, parent substance abuse, parent criminality, inter-parental violence, serious physical illness in childhood, and family economic adversity.Results: Mean age at menarche varied across decadal birth cohorts (χ2 (4) = 21.41, p < .001) ranging from a high of 12.9 years in the oldest cohort (age 59 or older at the time of interview) to a low of 12.4 in the second youngest cohort (age 28-37). Childhood adversities were also more common in younger than older cohorts. Of the 11 childhood adversities, 5 were associated with menarche at age 11 or earlier, with OR of 1.3 or greater. Each of these five adversities is associated with a 26% increase in the odds of early menarche (OR = 1.26, 95% CI 1.14-1.39). The relationship between childhood sexual abuse and early menarche was sustained after adjustment for co-occurring adversities. (OR = 1.77, 95% CI 1.21-2.6).Conclusions: Evidence from this study is consistent with hypothesized physiological effects of early childhood family environment on endocrine development. Childhood sexual abuse is the adversity most strongly associated with early menarche. However, because of the complex way that childhood adversities cluster within families, the more generalized influence of highly dysfunctional family environments cannot be ruled out.

AB - Background: Epidemiological evidence suggests that early menarche, defined as onset of menses at age 11 or earlier, has increased in prevalence in recent birth cohorts and is associated with multiple poor medical and mental health outcomes in adulthood. There is evidence that childhood adversities occurring prior to menarche contribute to early menarche.Methods: Data collected in face-to-face interviews with a nationally representative sample of women age 18 and over (N = 3288), as part of the National Comorbidity Survey-Replication, were analyzed. Associations between pre-menarchal childhood adversities and menarche at age 11 or earlier were estimated in discrete time survival models with statistical adjustment for age at interview, ethnicity, and body mass index. Adversities investigated included physical abuse, sexual abuse, neglect, biological father absence from the home, other parent loss, parent mental illness, parent substance abuse, parent criminality, inter-parental violence, serious physical illness in childhood, and family economic adversity.Results: Mean age at menarche varied across decadal birth cohorts (χ2 (4) = 21.41, p < .001) ranging from a high of 12.9 years in the oldest cohort (age 59 or older at the time of interview) to a low of 12.4 in the second youngest cohort (age 28-37). Childhood adversities were also more common in younger than older cohorts. Of the 11 childhood adversities, 5 were associated with menarche at age 11 or earlier, with OR of 1.3 or greater. Each of these five adversities is associated with a 26% increase in the odds of early menarche (OR = 1.26, 95% CI 1.14-1.39). The relationship between childhood sexual abuse and early menarche was sustained after adjustment for co-occurring adversities. (OR = 1.77, 95% CI 1.21-2.6).Conclusions: Evidence from this study is consistent with hypothesized physiological effects of early childhood family environment on endocrine development. Childhood sexual abuse is the adversity most strongly associated with early menarche. However, because of the complex way that childhood adversities cluster within families, the more generalized influence of highly dysfunctional family environments cannot be ruled out.

UR - http://www.scopus.com/inward/record.url?scp=84921451014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921451014&partnerID=8YFLogxK

U2 - 10.1186/1687-9856-2014-14

DO - 10.1186/1687-9856-2014-14

M3 - Article

AN - SCOPUS:84921451014

VL - 2014

JO - International Journal of Pediatric Endocrinology

JF - International Journal of Pediatric Endocrinology

SN - 1687-9848

IS - 1

M1 - 14

ER -