Abstract
Background: On May 20, 2016, US professional organizations in cardiology published joint treatment guidelines recommending the use of angiotensin-receptor neprilysin inhibitor (ARNI) for eligible patients with heart failure with reduced ejection fraction (HFrEF). Using data from the Get With The Guidelines–Heart Failure registry, we evaluated the early impact of this update on temporal trends in ARNI prescription. Methods: We analyzed patients with HFrEF who were eligible for ARNI prescription (EF ≤40%, no contraindications) and hospitalized from February 20, 2016, through August 19, 2016—allowing for 13 weeks before and after guideline publication. We quantified trends in ARNI use associated with guidelines publication with an interrupted time-series design using logistic regression and accounting for correlations within hospitals using general estimating equation methods. Results: Of 7,200 eligible patient hospitalizations, 51.9% were discharged in the period directly preceding publication of the guidelines, and 48.1% were discharged after. Odds ratios of ARNI prescription at discharge were significantly higher in the postguideline period compared with the preguideline period in adjusted models (adjusted odds ratio 1.29, 95% CI 1.06-1.57, P =.01). However, there was no significant interaction between observed and expected ARNI use after guideline publication (P interaction =.14). Results were consistent using a 6-month before and after time frame. Conclusions: The model suggested a small increase in ARNI use in HF patients being discharged from the hospital immediately after guideline release. However, the publication of national guidelines recommending ARNI use seemed to have little influence on the adoption of this evidence-based medication in the first 3 to 6 months.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 134-140 |
| Number of pages | 7 |
| Journal | American heart journal |
| Volume | 200 |
| DOIs | |
| State | Published - Jun 2018 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Early impact of guideline publication on angiotensin-receptor neprilysin inhibitor use among patients hospitalized for heart failure. / Luo, Nancy; Ballew, Nicholas G.; O'Brien, Emily C.; Greiner, Melissa A.; Peterson, Pamela N.; Hammill, Bradley G.; Hardy, N. Chantelle; Laskey, Warren K.; Heidenreich, Paul A.; Chang, Chun Lan; Hernandez, Adrian F.; Curtis, Lesley H.; Mentz, Robert J.; Fonarow, Gregg C.
In: American heart journal, Vol. 200, 06.2018, p. 134-140.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early impact of guideline publication on angiotensin-receptor neprilysin inhibitor use among patients hospitalized for heart failure
AU - Luo, Nancy
AU - Ballew, Nicholas G.
AU - O'Brien, Emily C.
AU - Greiner, Melissa A.
AU - Peterson, Pamela N.
AU - Hammill, Bradley G.
AU - Hardy, N. Chantelle
AU - Laskey, Warren K.
AU - Heidenreich, Paul A.
AU - Chang, Chun Lan
AU - Hernandez, Adrian F.
AU - Curtis, Lesley H.
AU - Mentz, Robert J.
AU - Fonarow, Gregg C.
PY - 2018/6
Y1 - 2018/6
N2 - Background: On May 20, 2016, US professional organizations in cardiology published joint treatment guidelines recommending the use of angiotensin-receptor neprilysin inhibitor (ARNI) for eligible patients with heart failure with reduced ejection fraction (HFrEF). Using data from the Get With The Guidelines–Heart Failure registry, we evaluated the early impact of this update on temporal trends in ARNI prescription. Methods: We analyzed patients with HFrEF who were eligible for ARNI prescription (EF ≤40%, no contraindications) and hospitalized from February 20, 2016, through August 19, 2016—allowing for 13 weeks before and after guideline publication. We quantified trends in ARNI use associated with guidelines publication with an interrupted time-series design using logistic regression and accounting for correlations within hospitals using general estimating equation methods. Results: Of 7,200 eligible patient hospitalizations, 51.9% were discharged in the period directly preceding publication of the guidelines, and 48.1% were discharged after. Odds ratios of ARNI prescription at discharge were significantly higher in the postguideline period compared with the preguideline period in adjusted models (adjusted odds ratio 1.29, 95% CI 1.06-1.57, P =.01). However, there was no significant interaction between observed and expected ARNI use after guideline publication (P interaction =.14). Results were consistent using a 6-month before and after time frame. Conclusions: The model suggested a small increase in ARNI use in HF patients being discharged from the hospital immediately after guideline release. However, the publication of national guidelines recommending ARNI use seemed to have little influence on the adoption of this evidence-based medication in the first 3 to 6 months.
AB - Background: On May 20, 2016, US professional organizations in cardiology published joint treatment guidelines recommending the use of angiotensin-receptor neprilysin inhibitor (ARNI) for eligible patients with heart failure with reduced ejection fraction (HFrEF). Using data from the Get With The Guidelines–Heart Failure registry, we evaluated the early impact of this update on temporal trends in ARNI prescription. Methods: We analyzed patients with HFrEF who were eligible for ARNI prescription (EF ≤40%, no contraindications) and hospitalized from February 20, 2016, through August 19, 2016—allowing for 13 weeks before and after guideline publication. We quantified trends in ARNI use associated with guidelines publication with an interrupted time-series design using logistic regression and accounting for correlations within hospitals using general estimating equation methods. Results: Of 7,200 eligible patient hospitalizations, 51.9% were discharged in the period directly preceding publication of the guidelines, and 48.1% were discharged after. Odds ratios of ARNI prescription at discharge were significantly higher in the postguideline period compared with the preguideline period in adjusted models (adjusted odds ratio 1.29, 95% CI 1.06-1.57, P =.01). However, there was no significant interaction between observed and expected ARNI use after guideline publication (P interaction =.14). Results were consistent using a 6-month before and after time frame. Conclusions: The model suggested a small increase in ARNI use in HF patients being discharged from the hospital immediately after guideline release. However, the publication of national guidelines recommending ARNI use seemed to have little influence on the adoption of this evidence-based medication in the first 3 to 6 months.
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U2 - 10.1016/j.ahj.2018.01.009
DO - 10.1016/j.ahj.2018.01.009
M3 - Article
C2 - 29898842
AN - SCOPUS:85043336082
VL - 200
SP - 134
EP - 140
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
ER -