Early identification and interventions for autism spectrum disorder: Executive summary

Lonnie Zwaigenbaum, Margaret L. Bauman, Roula Choueiri, Deborah Fein, Connie Kasari, Karen Pierce, Wendy L. Stone, Nurit Yirmiya, Annette Estes, Robin L Hansen, James C. McPartland, Marvin R. Natowicz, Timothy Buie, Alice Carter, Patricia A. Davis, Doreen Granpeesheh, Zoe Mailloux, Craig Newschaffer, Diana Robins, Susanne Smith RoleySheldon Wagner, Amy Wetherby

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impaired social communication skills and isolated areas of interest.1 The current prevalence of these disorders is estimated to be 1 in 68, 2 and recent estimates of the risk of recurrence in families with at least 1 child diagnosed with ASD are 10% to 19%.3-5 Advances have been made in identifying genetic variants that can account for biological vulnerability to ASD, 6, 7 although recent studies examining patterns of heredity implicate environmental factors and potential gene-by-environment interactions.8 Although the exact etiology remains unknown in most families, some researchers suggest that the pathogenesis of the disorder begins during prenatal life.9, 10 It is likely that ASD is heterogeneous in its etiology as well as in its clinical presentation.

Original languageEnglish (US)
Pages (from-to)S1-S9
JournalPediatrics
Volume136
DOIs
StatePublished - Oct 1 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Zwaigenbaum, L., Bauman, M. L., Choueiri, R., Fein, D., Kasari, C., Pierce, K., Stone, W. L., Yirmiya, N., Estes, A., Hansen, R. L., McPartland, J. C., Natowicz, M. R., Buie, T., Carter, A., Davis, P. A., Granpeesheh, D., Mailloux, Z., Newschaffer, C., Robins, D., ... Wetherby, A. (2015). Early identification and interventions for autism spectrum disorder: Executive summary. Pediatrics, 136, S1-S9. https://doi.org/10.1542/peds.2014-3667B