Abstract
Early hematologic changes were studied over a 14 day period in three groups of six rhesus macaques intravenously infected with pathogenic and nonpathogenic isolates of SIVmac. Abnormalities in blood included a mild blood loss anemia, sporadic lymphopenia, and variable CD4+ and CD8+ T lymphocyte numbers. Prominent bone marrow findings in macaques inoculated with pathogenic uncloned SIVmac and molecularly cloned pathogenic SIVmac-239 were hypercellularity, myeloid and megakaryocytic hyperplasia, and lymphoid aggregates. Infrequent mild morphologic abnormalities were present in macaques infected with a nonpathogenic molecular clone, SIVmac-1A11.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 177-186 |
| Number of pages | 10 |
| Journal | Journal of Medical Primatology |
| Volume | 22 |
| Issue number | 2-3 |
| State | Published - Feb 1993 |
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ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
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Early hematologic changes in rhesus macaques (Macaca mulatta) infected with pathogenic and nonpathogenic isolates of SIVmac. / Mandell, C. P.; Jain, N. C.; Miller, Chris J; Marthas, Marta; Dandekar, Satya.
In: Journal of Medical Primatology, Vol. 22, No. 2-3, 02.1993, p. 177-186.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Early hematologic changes in rhesus macaques (Macaca mulatta) infected with pathogenic and nonpathogenic isolates of SIVmac.
AU - Mandell, C. P.
AU - Jain, N. C.
AU - Miller, Chris J
AU - Marthas, Marta
AU - Dandekar, Satya
PY - 1993/2
Y1 - 1993/2
N2 - Early hematologic changes were studied over a 14 day period in three groups of six rhesus macaques intravenously infected with pathogenic and nonpathogenic isolates of SIVmac. Abnormalities in blood included a mild blood loss anemia, sporadic lymphopenia, and variable CD4+ and CD8+ T lymphocyte numbers. Prominent bone marrow findings in macaques inoculated with pathogenic uncloned SIVmac and molecularly cloned pathogenic SIVmac-239 were hypercellularity, myeloid and megakaryocytic hyperplasia, and lymphoid aggregates. Infrequent mild morphologic abnormalities were present in macaques infected with a nonpathogenic molecular clone, SIVmac-1A11.
AB - Early hematologic changes were studied over a 14 day period in three groups of six rhesus macaques intravenously infected with pathogenic and nonpathogenic isolates of SIVmac. Abnormalities in blood included a mild blood loss anemia, sporadic lymphopenia, and variable CD4+ and CD8+ T lymphocyte numbers. Prominent bone marrow findings in macaques inoculated with pathogenic uncloned SIVmac and molecularly cloned pathogenic SIVmac-239 were hypercellularity, myeloid and megakaryocytic hyperplasia, and lymphoid aggregates. Infrequent mild morphologic abnormalities were present in macaques infected with a nonpathogenic molecular clone, SIVmac-1A11.
UR - http://www.scopus.com/inward/record.url?scp=0027549059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027549059&partnerID=8YFLogxK
M3 - Article
VL - 22
SP - 177
EP - 186
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 2-3
ER -