Abstract
Early hematologic changes were studied over a 14 day period in three groups of six rhesus macaques intravenously infected with pathogenic and nonpathogenic isolates of SIVmac. Abnormalities in blood included a mild blood loss anemia, sporadic lymphopenia, and variable CD4+ and CD8+ T lymphocyte numbers. Prominent bone marrow findings in macaques inoculated with pathogenic uncloned SIVmac and molecularly cloned pathogenic SIVmac-239 were hypercellularity, myeloid and megakaryocytic hyperplasia, and lymphoid aggregates. Infrequent mild morphologic abnormalities were present in macaques infected with a nonpathogenic molecular clone, SIVmac-1A11.
Original language | English (US) |
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Pages (from-to) | 177-186 |
Number of pages | 10 |
Journal | Journal of Medical Primatology |
Volume | 22 |
Issue number | 2-3 |
State | Published - Feb 1993 |
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)