Abstract
Objectives: To examine whether specific types of early functional limitations in cognitively normal older adults are associated with subsequent development of mild cognitive impairment (MCI), as well as the relative predictive value of self versus informant report in predicting diagnostic conversion to MCI. Design: As a part of a longitudinal study design, participants underwent baseline and annual multidisciplinary clinical evaluations, including a physical and neurological examination, imaging, laboratory work, and neuropsychological testing. Setting: Data used in this study were collected as part of longitudinal research at the University of California, Davis Alzheimer's Disease Center. Participants: Individuals diagnosed as having normal cognition at study baseline who had an informant who could complete informant-based ratings and at least one follow-up visit (N = 324). Measurements: Participants and informants each completed the Everyday Cognition Scale (ECog), an instrument designed to measure everyday function in six cognitively relevant domains. Results: Self- and informant-reported functional limitations on the ECog were associated with significantly greater risk of diagnostic conversion to MCI (informant: hazard ratio (HR) = 2.0, 95% confidence interval (CI) = 1.3-3.2, P = .002), with self-report having a slightly higher hazard (HR = 2.3, 95% CI = 1.4-3.6, P < .001). When controlling for baseline cognitive abilities, the effect remained significant for self- and informant-reported functional limitations. Conclusion: Deficits in everyday memory and executive function domains were the strongest predictors of diagnostic conversion to MCI. Detection of early functional limitations may be clinically useful in assessing the future risk of developing cognitive impairment in cognitively normal older adults.
| Original language | English (US) |
|---|---|
| Journal | Journal of the American Geriatrics Society |
| DOIs | |
| State | Accepted/In press - 2017 |
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Keywords
- Functional ability
- Informant report
- Mild cognitive impairment
- Normal cognition
- Self-report
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
Early Functional Limitations in Cognitively Normal Older Adults Predict Diagnostic Conversion to Mild Cognitive Impairment. / Tomaszewski Farias, Sarah E; Lau, Karen; Harvey, Danielle J; Denny, Katherine; Barba, Cheyanne; Mefford, Anthony N.
In: Journal of the American Geriatrics Society, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early Functional Limitations in Cognitively Normal Older Adults Predict Diagnostic Conversion to Mild Cognitive Impairment
AU - Tomaszewski Farias, Sarah E
AU - Lau, Karen
AU - Harvey, Danielle J
AU - Denny, Katherine
AU - Barba, Cheyanne
AU - Mefford, Anthony N.
PY - 2017
Y1 - 2017
N2 - Objectives: To examine whether specific types of early functional limitations in cognitively normal older adults are associated with subsequent development of mild cognitive impairment (MCI), as well as the relative predictive value of self versus informant report in predicting diagnostic conversion to MCI. Design: As a part of a longitudinal study design, participants underwent baseline and annual multidisciplinary clinical evaluations, including a physical and neurological examination, imaging, laboratory work, and neuropsychological testing. Setting: Data used in this study were collected as part of longitudinal research at the University of California, Davis Alzheimer's Disease Center. Participants: Individuals diagnosed as having normal cognition at study baseline who had an informant who could complete informant-based ratings and at least one follow-up visit (N = 324). Measurements: Participants and informants each completed the Everyday Cognition Scale (ECog), an instrument designed to measure everyday function in six cognitively relevant domains. Results: Self- and informant-reported functional limitations on the ECog were associated with significantly greater risk of diagnostic conversion to MCI (informant: hazard ratio (HR) = 2.0, 95% confidence interval (CI) = 1.3-3.2, P = .002), with self-report having a slightly higher hazard (HR = 2.3, 95% CI = 1.4-3.6, P < .001). When controlling for baseline cognitive abilities, the effect remained significant for self- and informant-reported functional limitations. Conclusion: Deficits in everyday memory and executive function domains were the strongest predictors of diagnostic conversion to MCI. Detection of early functional limitations may be clinically useful in assessing the future risk of developing cognitive impairment in cognitively normal older adults.
AB - Objectives: To examine whether specific types of early functional limitations in cognitively normal older adults are associated with subsequent development of mild cognitive impairment (MCI), as well as the relative predictive value of self versus informant report in predicting diagnostic conversion to MCI. Design: As a part of a longitudinal study design, participants underwent baseline and annual multidisciplinary clinical evaluations, including a physical and neurological examination, imaging, laboratory work, and neuropsychological testing. Setting: Data used in this study were collected as part of longitudinal research at the University of California, Davis Alzheimer's Disease Center. Participants: Individuals diagnosed as having normal cognition at study baseline who had an informant who could complete informant-based ratings and at least one follow-up visit (N = 324). Measurements: Participants and informants each completed the Everyday Cognition Scale (ECog), an instrument designed to measure everyday function in six cognitively relevant domains. Results: Self- and informant-reported functional limitations on the ECog were associated with significantly greater risk of diagnostic conversion to MCI (informant: hazard ratio (HR) = 2.0, 95% confidence interval (CI) = 1.3-3.2, P = .002), with self-report having a slightly higher hazard (HR = 2.3, 95% CI = 1.4-3.6, P < .001). When controlling for baseline cognitive abilities, the effect remained significant for self- and informant-reported functional limitations. Conclusion: Deficits in everyday memory and executive function domains were the strongest predictors of diagnostic conversion to MCI. Detection of early functional limitations may be clinically useful in assessing the future risk of developing cognitive impairment in cognitively normal older adults.
KW - Functional ability
KW - Informant report
KW - Mild cognitive impairment
KW - Normal cognition
KW - Self-report
UR - http://www.scopus.com/inward/record.url?scp=85017102465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017102465&partnerID=8YFLogxK
U2 - 10.1111/jgs.14835
DO - 10.1111/jgs.14835
M3 - Article
C2 - 28306147
AN - SCOPUS:85017102465
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
SN - 0002-8614
ER -