Early effector T cells producing significant IFN-γ develop into memory

J. Jeremiah Bell, Jason S. Ellis, F. Betul Guloglu, Danielle Tartar, Hyun Hee Lee, Rohit D. Divekar, Renu Jain, Ping Yu, Christine M. Hoeman, Habib Zaghouani

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Currently, transition of T cells from effector to memory is believed to occur as a consequence of exposure to residual suboptimal Ag found in lymphoid tissues at the waning end of the effector phase and microbial clearance. This led to the interpretation that memory arises from slightly activated late effectors producing reduced amounts of IFN-γ. In this study, we show that CD4 T cells from the early stage of the effector phase in which both the Ag and activation are optimal also transit to memory. Moreover, early effector T cells that have undergone four divisions expressed significant IL-7R, produced IFN-γ, and yielded rapid and robust memory responses. Cells that divided three times that had marginal IL-7R expression and no IFN-γ raised base level homeostatic memory, whereas those that have undergone only two divisions and produced IFN-γ yielded conditioned memory despite low IL-7R expression. Thus, highly activated early effectors generated under short exposure to optimal Ag in vivo develop into memory, and such transition is dependent on a significant production of the cell's signature cytokine, IFN-γ.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalJournal of Immunology
Volume180
Issue number1
StatePublished - Jan 1 2008
Externally publishedYes

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T-Lymphocytes
Lymphoid Tissue
Cytokines

ASJC Scopus subject areas

  • Immunology

Cite this

Bell, J. J., Ellis, J. S., Guloglu, F. B., Tartar, D., Lee, H. H., Divekar, R. D., ... Zaghouani, H. (2008). Early effector T cells producing significant IFN-γ develop into memory. Journal of Immunology, 180(1), 179-187.

Early effector T cells producing significant IFN-γ develop into memory. / Bell, J. Jeremiah; Ellis, Jason S.; Guloglu, F. Betul; Tartar, Danielle; Lee, Hyun Hee; Divekar, Rohit D.; Jain, Renu; Yu, Ping; Hoeman, Christine M.; Zaghouani, Habib.

In: Journal of Immunology, Vol. 180, No. 1, 01.01.2008, p. 179-187.

Research output: Contribution to journalArticle

Bell, JJ, Ellis, JS, Guloglu, FB, Tartar, D, Lee, HH, Divekar, RD, Jain, R, Yu, P, Hoeman, CM & Zaghouani, H 2008, 'Early effector T cells producing significant IFN-γ develop into memory', Journal of Immunology, vol. 180, no. 1, pp. 179-187.
Bell JJ, Ellis JS, Guloglu FB, Tartar D, Lee HH, Divekar RD et al. Early effector T cells producing significant IFN-γ develop into memory. Journal of Immunology. 2008 Jan 1;180(1):179-187.
Bell, J. Jeremiah ; Ellis, Jason S. ; Guloglu, F. Betul ; Tartar, Danielle ; Lee, Hyun Hee ; Divekar, Rohit D. ; Jain, Renu ; Yu, Ping ; Hoeman, Christine M. ; Zaghouani, Habib. / Early effector T cells producing significant IFN-γ develop into memory. In: Journal of Immunology. 2008 ; Vol. 180, No. 1. pp. 179-187.
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AU - Divekar, Rohit D.

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