Early diet impacts infant rhesus gut microbiome, immunity, and metabolism

Aifric O'Sullivan, Xuan He, Elizabeth M S McNiven, Neill W. Haggarty, Bo Lönnerdal, Carolyn M. Slupsky

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Epidemiological research has indicated a relationship between infant formula feeding and increased risk of chronic diseases later in life including obesity, type-2 diabetes, and cardiovascular disease. The present study used an infant rhesus monkey model to compare the comprehensive metabolic implications of formula- and breast-feeding practices using NMR spectroscopy to characterize metabolite fingerprints from urine and serum, in combination with anthropometric measurements, fecal microbial profiling, and cytokine measurements. Here we show that formula-fed infants are larger than their breast-fed counterparts and have a different gut microbiome that includes higher levels of bacteria from the Ruminococcus genus and lower levels of bacteria from the Lactobacillus genus. In addition, formula-fed infants have higher serum insulin coupled with higher amino acid levels, while amino acid degradation products were higher in breast-fed infants. Increases in serum and urine galactose and urine galactitol were observed in the second month of life in formula-fed infants, along with higher levels of TNFα, IFN-γ, IL-1β, IL-4, and other cytokines and growth factors at week 4. These results demonstrate that metabolic and gut microbiome development of formula-fed infants is different from breast-fed infants and that the choice of infant feeding may hold future health consequences.

Original languageEnglish (US)
Pages (from-to)2833-2845
Number of pages13
JournalJournal of Proteome Research
Volume12
Issue number6
DOIs
StatePublished - 2013

Fingerprint

Infant Formula
Nutrition
Metabolism
Immunity
Diet
Bacteria
Galactitol
Breast
Cytokines
Amino Acids
Urine
Medical problems
Metabolites
Galactose
Interleukin-1
Interleukin-4
Ruminococcus
Nuclear magnetic resonance spectroscopy
Serum
Intercellular Signaling Peptides and Proteins

Keywords

  • breast feeding
  • formula feeding
  • gut microbiota
  • immune system
  • infant
  • metabolism
  • metabolomics
  • microbiome
  • NMR spectroscopy
  • nutrition
  • pediatric

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

Cite this

O'Sullivan, A., He, X., McNiven, E. M. S., Haggarty, N. W., Lönnerdal, B., & Slupsky, C. M. (2013). Early diet impacts infant rhesus gut microbiome, immunity, and metabolism. Journal of Proteome Research, 12(6), 2833-2845. https://doi.org/10.1021/pr4001702

Early diet impacts infant rhesus gut microbiome, immunity, and metabolism. / O'Sullivan, Aifric; He, Xuan; McNiven, Elizabeth M S; Haggarty, Neill W.; Lönnerdal, Bo; Slupsky, Carolyn M.

In: Journal of Proteome Research, Vol. 12, No. 6, 2013, p. 2833-2845.

Research output: Contribution to journalArticle

O'Sullivan, A, He, X, McNiven, EMS, Haggarty, NW, Lönnerdal, B & Slupsky, CM 2013, 'Early diet impacts infant rhesus gut microbiome, immunity, and metabolism', Journal of Proteome Research, vol. 12, no. 6, pp. 2833-2845. https://doi.org/10.1021/pr4001702
O'Sullivan A, He X, McNiven EMS, Haggarty NW, Lönnerdal B, Slupsky CM. Early diet impacts infant rhesus gut microbiome, immunity, and metabolism. Journal of Proteome Research. 2013;12(6):2833-2845. https://doi.org/10.1021/pr4001702
O'Sullivan, Aifric ; He, Xuan ; McNiven, Elizabeth M S ; Haggarty, Neill W. ; Lönnerdal, Bo ; Slupsky, Carolyn M. / Early diet impacts infant rhesus gut microbiome, immunity, and metabolism. In: Journal of Proteome Research. 2013 ; Vol. 12, No. 6. pp. 2833-2845.
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