Early diagnosis of venous thrombosis using 125I fibrinogen

R. F. Carretta, S. J. DeNardo, G. L. DeNardo, A. L. Janshalt, A. W. Rose

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Twenty out of 102 patients studied with 125I fibrinogen had positive test results. Of these, acute thrombophlebitis was confirmed by radiopaque venography in 12 and by clinical evaluation and subsequent hospital course in eight. None of the 30 radiopaque venograms performed in patients with negative fibrinogen uptake tests revealed evidence of acute thrombophlebitis. Most significantly, 85% of the positive tests were evident within 24 hr after administration of the radiopharmaceutical, thus indicating the clinical value of this procedure. Forty two percent of 24 patients suspected of acute thrombophlebitis and 50% of 14 patients with documented pulmonary emboli had positive fibrinogen tests. Anticoagulation therapy did not prevent a positive 125I fibrinogen result. Followup studies, conducted 1-6 months after injection of 125I fibrinogen, showed no evidence of hepatitis in any of the recipients.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalJournal of Nuclear Medicine
Issue number1
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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