Early behavioral intervention is associated with normalized brain activity in young children with autism

Geraldine Dawson, Emily J H Jones, Kristen Merkle, Kaitlin Venema, Rachel Lowy, Susan Faja, Dana Kamara, Michael Murias, Jessica Greenson, Jamie Winter, Milani Smith, Sally J Rogers, Sara J. Webb

Research output: Contribution to journalArticle

266 Citations (Scopus)

Abstract

Objective: A previously published randomized clinical trial indicated that a developmental behavioral intervention, the Early Start Denver Model (ESDM), resulted in gains in IQ, language, and adaptive behavior of children with autism spectrum disorder. This report describes a secondary outcome measurement from this trial, EEG activity. Method: Forty-eight 18- to 30-month-old children with autism spectrum disorder were randomized to receive the ESDM or referral to community intervention for 2 years. After the intervention (age 48 to 77 months), EEG activity (event-related potentials and spectral power) was measured during the presentation of faces versus objects. Age-matched typical children were also assessed. Results: The ESDM group exhibited greater improvements in autism symptoms, IQ, language, and adaptive and social behaviors than the community intervention group. The ESDM group and typical children showed a shorter Nc latency and increased cortical activation (decreased α power and increased θ power) when viewing faces, whereas the community intervention group showed the opposite pattern (shorter latency event-related potential [ERP] and greater cortical activation when viewing objects). Greater cortical activation while viewing faces was associated with improved social behavior. Conclusions: This was the first trial to demonstrate that early behavioral intervention is associated with normalized patterns of brain activity, which is associated with improvements in social behavior, in young children with autism spectrum disorder.

Original languageEnglish (US)
Pages (from-to)1150-1159
Number of pages10
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume51
Issue number11
DOIs
StatePublished - Nov 2012

Fingerprint

Autistic Disorder
Social Behavior
Brain
Psychological Adaptation
Evoked Potentials
Electroencephalography
Language
Referral and Consultation
Randomized Controlled Trials
Autism Spectrum Disorder
Power (Psychology)

Keywords

  • autism
  • brain activity
  • early behavioral intervention
  • Early Start Denver Model
  • event-related potentials

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

Early behavioral intervention is associated with normalized brain activity in young children with autism. / Dawson, Geraldine; Jones, Emily J H; Merkle, Kristen; Venema, Kaitlin; Lowy, Rachel; Faja, Susan; Kamara, Dana; Murias, Michael; Greenson, Jessica; Winter, Jamie; Smith, Milani; Rogers, Sally J; Webb, Sara J.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 51, No. 11, 11.2012, p. 1150-1159.

Research output: Contribution to journalArticle

Dawson, G, Jones, EJH, Merkle, K, Venema, K, Lowy, R, Faja, S, Kamara, D, Murias, M, Greenson, J, Winter, J, Smith, M, Rogers, SJ & Webb, SJ 2012, 'Early behavioral intervention is associated with normalized brain activity in young children with autism', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 51, no. 11, pp. 1150-1159. https://doi.org/10.1016/j.jaac.2012.08.018
Dawson, Geraldine ; Jones, Emily J H ; Merkle, Kristen ; Venema, Kaitlin ; Lowy, Rachel ; Faja, Susan ; Kamara, Dana ; Murias, Michael ; Greenson, Jessica ; Winter, Jamie ; Smith, Milani ; Rogers, Sally J ; Webb, Sara J. / Early behavioral intervention is associated with normalized brain activity in young children with autism. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2012 ; Vol. 51, No. 11. pp. 1150-1159.
@article{cf21e4c471e94847bef8aa9d3d24a6ae,
title = "Early behavioral intervention is associated with normalized brain activity in young children with autism",
abstract = "Objective: A previously published randomized clinical trial indicated that a developmental behavioral intervention, the Early Start Denver Model (ESDM), resulted in gains in IQ, language, and adaptive behavior of children with autism spectrum disorder. This report describes a secondary outcome measurement from this trial, EEG activity. Method: Forty-eight 18- to 30-month-old children with autism spectrum disorder were randomized to receive the ESDM or referral to community intervention for 2 years. After the intervention (age 48 to 77 months), EEG activity (event-related potentials and spectral power) was measured during the presentation of faces versus objects. Age-matched typical children were also assessed. Results: The ESDM group exhibited greater improvements in autism symptoms, IQ, language, and adaptive and social behaviors than the community intervention group. The ESDM group and typical children showed a shorter Nc latency and increased cortical activation (decreased α power and increased θ power) when viewing faces, whereas the community intervention group showed the opposite pattern (shorter latency event-related potential [ERP] and greater cortical activation when viewing objects). Greater cortical activation while viewing faces was associated with improved social behavior. Conclusions: This was the first trial to demonstrate that early behavioral intervention is associated with normalized patterns of brain activity, which is associated with improvements in social behavior, in young children with autism spectrum disorder.",
keywords = "autism, brain activity, early behavioral intervention, Early Start Denver Model, event-related potentials",
author = "Geraldine Dawson and Jones, {Emily J H} and Kristen Merkle and Kaitlin Venema and Rachel Lowy and Susan Faja and Dana Kamara and Michael Murias and Jessica Greenson and Jamie Winter and Milani Smith and Rogers, {Sally J} and Webb, {Sara J.}",
year = "2012",
month = "11",
doi = "10.1016/j.jaac.2012.08.018",
language = "English (US)",
volume = "51",
pages = "1150--1159",
journal = "Journal of the American Academy of Child and Adolescent Psychiatry",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Early behavioral intervention is associated with normalized brain activity in young children with autism

AU - Dawson, Geraldine

AU - Jones, Emily J H

AU - Merkle, Kristen

AU - Venema, Kaitlin

AU - Lowy, Rachel

AU - Faja, Susan

AU - Kamara, Dana

AU - Murias, Michael

AU - Greenson, Jessica

AU - Winter, Jamie

AU - Smith, Milani

AU - Rogers, Sally J

AU - Webb, Sara J.

PY - 2012/11

Y1 - 2012/11

N2 - Objective: A previously published randomized clinical trial indicated that a developmental behavioral intervention, the Early Start Denver Model (ESDM), resulted in gains in IQ, language, and adaptive behavior of children with autism spectrum disorder. This report describes a secondary outcome measurement from this trial, EEG activity. Method: Forty-eight 18- to 30-month-old children with autism spectrum disorder were randomized to receive the ESDM or referral to community intervention for 2 years. After the intervention (age 48 to 77 months), EEG activity (event-related potentials and spectral power) was measured during the presentation of faces versus objects. Age-matched typical children were also assessed. Results: The ESDM group exhibited greater improvements in autism symptoms, IQ, language, and adaptive and social behaviors than the community intervention group. The ESDM group and typical children showed a shorter Nc latency and increased cortical activation (decreased α power and increased θ power) when viewing faces, whereas the community intervention group showed the opposite pattern (shorter latency event-related potential [ERP] and greater cortical activation when viewing objects). Greater cortical activation while viewing faces was associated with improved social behavior. Conclusions: This was the first trial to demonstrate that early behavioral intervention is associated with normalized patterns of brain activity, which is associated with improvements in social behavior, in young children with autism spectrum disorder.

AB - Objective: A previously published randomized clinical trial indicated that a developmental behavioral intervention, the Early Start Denver Model (ESDM), resulted in gains in IQ, language, and adaptive behavior of children with autism spectrum disorder. This report describes a secondary outcome measurement from this trial, EEG activity. Method: Forty-eight 18- to 30-month-old children with autism spectrum disorder were randomized to receive the ESDM or referral to community intervention for 2 years. After the intervention (age 48 to 77 months), EEG activity (event-related potentials and spectral power) was measured during the presentation of faces versus objects. Age-matched typical children were also assessed. Results: The ESDM group exhibited greater improvements in autism symptoms, IQ, language, and adaptive and social behaviors than the community intervention group. The ESDM group and typical children showed a shorter Nc latency and increased cortical activation (decreased α power and increased θ power) when viewing faces, whereas the community intervention group showed the opposite pattern (shorter latency event-related potential [ERP] and greater cortical activation when viewing objects). Greater cortical activation while viewing faces was associated with improved social behavior. Conclusions: This was the first trial to demonstrate that early behavioral intervention is associated with normalized patterns of brain activity, which is associated with improvements in social behavior, in young children with autism spectrum disorder.

KW - autism

KW - brain activity

KW - early behavioral intervention

KW - Early Start Denver Model

KW - event-related potentials

UR - http://www.scopus.com/inward/record.url?scp=84867891791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867891791&partnerID=8YFLogxK

U2 - 10.1016/j.jaac.2012.08.018

DO - 10.1016/j.jaac.2012.08.018

M3 - Article

C2 - 23101741

AN - SCOPUS:84867891791

VL - 51

SP - 1150

EP - 1159

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

SN - 0890-8567

IS - 11

ER -