TY - JOUR
T1 - Earlier onset of Alzheimer disease symptoms in latino individuals compared with anglo individuals
AU - Clark, Christopher M.
AU - DeCarli, Charles
AU - Mungas, Dan M
AU - Chui, Helena I.
AU - Higdon, Roger
AU - Nuñez, Jessica
AU - Fernandez, Henrique
AU - Negrón, Mirna
AU - Manly, Jennifer
AU - Ferris, Steven
AU - Perez, Angelica
AU - Torres, Migdalia
AU - Ewbank, Douglas
AU - Glosser, Guila
AU - Van Belle, Gerald
PY - 2005/5
Y1 - 2005/5
N2 - Background: Latino individuals are the largest minority group and the fastest growing population group in the United States, yet there are few studies comparing the clinical features of Alzheimer disease (AD) in this population with those found in Anglo (white non-Latino) patients. Objective: To compare the age at AD symptom onset in Latino and Anglo individuals. Design: Cross-sectional assessment using standardized methods to collect and compare age at AD symptom onset, demographic variables, and medical variables. Setting: Five National Institute on Aging-sponsored Alzheimer's Disease Centers with experience evaluating Spanish-speaking individuals. Patients: We evaluated 119 Latino and 55 Anglo patients who had a diagnosis of AD. Main Outcome Measure: Age at symptom onset. Results: After adjusting for center, sex, and years of education, Latino patients had a mean age at symptom onset 6.8 years earlier (95% confidence interval, 3.5-10.3 years earlier) than Anglo patients. Conclusions: An earlier age at symptom onset suggests that US mainland Latino individuals may experience an increased burden of AD compared with Anglo individuals. The basis for the younger age at symptom onset remains obscure.
AB - Background: Latino individuals are the largest minority group and the fastest growing population group in the United States, yet there are few studies comparing the clinical features of Alzheimer disease (AD) in this population with those found in Anglo (white non-Latino) patients. Objective: To compare the age at AD symptom onset in Latino and Anglo individuals. Design: Cross-sectional assessment using standardized methods to collect and compare age at AD symptom onset, demographic variables, and medical variables. Setting: Five National Institute on Aging-sponsored Alzheimer's Disease Centers with experience evaluating Spanish-speaking individuals. Patients: We evaluated 119 Latino and 55 Anglo patients who had a diagnosis of AD. Main Outcome Measure: Age at symptom onset. Results: After adjusting for center, sex, and years of education, Latino patients had a mean age at symptom onset 6.8 years earlier (95% confidence interval, 3.5-10.3 years earlier) than Anglo patients. Conclusions: An earlier age at symptom onset suggests that US mainland Latino individuals may experience an increased burden of AD compared with Anglo individuals. The basis for the younger age at symptom onset remains obscure.
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U2 - 10.1001/archneur.62.5.774
DO - 10.1001/archneur.62.5.774
M3 - Article
C2 - 15883265
AN - SCOPUS:20844458951
VL - 62
SP - 774
EP - 778
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 5
ER -