Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks

David G. Weissman, Roberta A. Schriber, Catherine Fassbender, Olivia Atherton, Cynthia Krafft, Richard W. Robins, Paul D. Hastings, Amanda E. Guyer

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background Early adolescent onset of substance use is a robust predictor of future substance use disorders. We examined the relation between age of substance use initiation and resting state functional connectivity (RSFC) of the core reward processing (nucleus accumbens; NAcc) to cognitive control (prefrontal cortex; PFC) brain networks. Method Adolescents in a longitudinal study of Mexican-origin youth reported their substance use annually from ages 10 to 16 years. At age 16, 69 adolescents participated in a resting state functional magnetic resonance imaging scan. Seed-based correlational analyses were conducted using regions of interest in bilateral NAcc. Results The earlier that adolescents initiated substance use, the stronger the connectivity between bilateral NAcc and right dorsolateral PFC, right dorsomedial PFC, right pre-supplementary motor area, right inferior parietal lobule, and left medial temporal gyrus. Discussion The regions that demonstrated significant positive linear relationships between the number of adolescent years using substances and connectivity with NAcc are nodes in the right frontoparietal network, which is central to cognitive control. The coupling of reward and cognitive control networks may be a mechanism through which earlier onset of substance use is related to brain function over time, a trajectory that may be implicated in subsequent substance use disorders.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalDevelopmental Cognitive Neuroscience
Volume16
DOIs
StatePublished - Dec 1 2015

Fingerprint

Reward
Brain
Substance-Related Disorders
Parietal Lobe
Nucleus Accumbens
Motor Cortex
Temporal Lobe
Prefrontal Cortex
Longitudinal Studies
Seeds
Magnetic Resonance Imaging

Keywords

  • Adolescence
  • Cognitive regulation
  • fMRI
  • Resting state
  • Striatum

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks. / Weissman, David G.; Schriber, Roberta A.; Fassbender, Catherine; Atherton, Olivia; Krafft, Cynthia; Robins, Richard W.; Hastings, Paul D.; Guyer, Amanda E.

In: Developmental Cognitive Neuroscience, Vol. 16, 01.12.2015, p. 121-129.

Research output: Contribution to journalArticle

Weissman, David G. ; Schriber, Roberta A. ; Fassbender, Catherine ; Atherton, Olivia ; Krafft, Cynthia ; Robins, Richard W. ; Hastings, Paul D. ; Guyer, Amanda E. / Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks. In: Developmental Cognitive Neuroscience. 2015 ; Vol. 16. pp. 121-129.
@article{9d49794a0573443c8faa28e94f5036ef,
title = "Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks",
abstract = "Background Early adolescent onset of substance use is a robust predictor of future substance use disorders. We examined the relation between age of substance use initiation and resting state functional connectivity (RSFC) of the core reward processing (nucleus accumbens; NAcc) to cognitive control (prefrontal cortex; PFC) brain networks. Method Adolescents in a longitudinal study of Mexican-origin youth reported their substance use annually from ages 10 to 16 years. At age 16, 69 adolescents participated in a resting state functional magnetic resonance imaging scan. Seed-based correlational analyses were conducted using regions of interest in bilateral NAcc. Results The earlier that adolescents initiated substance use, the stronger the connectivity between bilateral NAcc and right dorsolateral PFC, right dorsomedial PFC, right pre-supplementary motor area, right inferior parietal lobule, and left medial temporal gyrus. Discussion The regions that demonstrated significant positive linear relationships between the number of adolescent years using substances and connectivity with NAcc are nodes in the right frontoparietal network, which is central to cognitive control. The coupling of reward and cognitive control networks may be a mechanism through which earlier onset of substance use is related to brain function over time, a trajectory that may be implicated in subsequent substance use disorders.",
keywords = "Adolescence, Cognitive regulation, fMRI, Resting state, Striatum",
author = "Weissman, {David G.} and Schriber, {Roberta A.} and Catherine Fassbender and Olivia Atherton and Cynthia Krafft and Robins, {Richard W.} and Hastings, {Paul D.} and Guyer, {Amanda E.}",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.dcn.2015.07.002",
language = "English (US)",
volume = "16",
pages = "121--129",
journal = "Developmental Cognitive Neuroscience",
issn = "1878-9293",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks

AU - Weissman, David G.

AU - Schriber, Roberta A.

AU - Fassbender, Catherine

AU - Atherton, Olivia

AU - Krafft, Cynthia

AU - Robins, Richard W.

AU - Hastings, Paul D.

AU - Guyer, Amanda E.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background Early adolescent onset of substance use is a robust predictor of future substance use disorders. We examined the relation between age of substance use initiation and resting state functional connectivity (RSFC) of the core reward processing (nucleus accumbens; NAcc) to cognitive control (prefrontal cortex; PFC) brain networks. Method Adolescents in a longitudinal study of Mexican-origin youth reported their substance use annually from ages 10 to 16 years. At age 16, 69 adolescents participated in a resting state functional magnetic resonance imaging scan. Seed-based correlational analyses were conducted using regions of interest in bilateral NAcc. Results The earlier that adolescents initiated substance use, the stronger the connectivity between bilateral NAcc and right dorsolateral PFC, right dorsomedial PFC, right pre-supplementary motor area, right inferior parietal lobule, and left medial temporal gyrus. Discussion The regions that demonstrated significant positive linear relationships between the number of adolescent years using substances and connectivity with NAcc are nodes in the right frontoparietal network, which is central to cognitive control. The coupling of reward and cognitive control networks may be a mechanism through which earlier onset of substance use is related to brain function over time, a trajectory that may be implicated in subsequent substance use disorders.

AB - Background Early adolescent onset of substance use is a robust predictor of future substance use disorders. We examined the relation between age of substance use initiation and resting state functional connectivity (RSFC) of the core reward processing (nucleus accumbens; NAcc) to cognitive control (prefrontal cortex; PFC) brain networks. Method Adolescents in a longitudinal study of Mexican-origin youth reported their substance use annually from ages 10 to 16 years. At age 16, 69 adolescents participated in a resting state functional magnetic resonance imaging scan. Seed-based correlational analyses were conducted using regions of interest in bilateral NAcc. Results The earlier that adolescents initiated substance use, the stronger the connectivity between bilateral NAcc and right dorsolateral PFC, right dorsomedial PFC, right pre-supplementary motor area, right inferior parietal lobule, and left medial temporal gyrus. Discussion The regions that demonstrated significant positive linear relationships between the number of adolescent years using substances and connectivity with NAcc are nodes in the right frontoparietal network, which is central to cognitive control. The coupling of reward and cognitive control networks may be a mechanism through which earlier onset of substance use is related to brain function over time, a trajectory that may be implicated in subsequent substance use disorders.

KW - Adolescence

KW - Cognitive regulation

KW - fMRI

KW - Resting state

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=84937695829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937695829&partnerID=8YFLogxK

U2 - 10.1016/j.dcn.2015.07.002

DO - 10.1016/j.dcn.2015.07.002

M3 - Article

VL - 16

SP - 121

EP - 129

JO - Developmental Cognitive Neuroscience

JF - Developmental Cognitive Neuroscience

SN - 1878-9293

ER -