E3 ubiquitin ligases in ErbB receptor quantity control

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27 Scopus citations

Abstract

Signaling through ErbB family growth factor receptor tyrosine kinases is necessary for the development and homeostasis of a wide variety of tissue types. However, the intensity of receptor-mediated cellular signaling must fall within a precise range; insufficient signaling can lead to developmental abnormalities or tissue atrophy, while over-signaling can lead to hyperplastic and ultimately neoplastic events. While a plethora of mechanisms have been described that regulate downstream signaling events, it appears that cells also utilize various mechanisms to regulate their ErbB receptor levels. Such mechanisms are collectively termed " ErbB receptor quantity control." Notably, studies over the past few years have highlighted roles for post-transcriptional processes, particularly protein degradation, in ErbB quantity control. Here the involvement of ErbB-directed E3 ubiquitin ligases is discussed, including Nrdp1-mediated ErbB3 degradation, ErbB4 degradation mediated by Nedd4 family E3 ligases, and CHIP-mediated ErbB2 degradation. The hypothesis is forwarded that protein degradation-based ErbB quantity control mechanisms play central roles in suppressing receptor overexpression in normal cells, and that the loss of such mechanisms could facilitate the onset or progression of ErbB-dependent tumors.

Original languageEnglish (US)
Pages (from-to)936-943
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume21
Issue number9
DOIs
StatePublished - Dec 2010

Keywords

  • Cancer
  • Degradation
  • E3 ubiqutin ligase
  • ErbB receptor
  • Ubiquitination

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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