Dysregulation of the fibroblast growth factor system in major depression

S. J. Evans, Prabhakara V Choudary, C. R. Neal, J. Z. Li, M. P. Vawter, H. Tomita, J. F. Lopez, R. C. Thompson, F. Meng, J. D. Stead, D. M. Walsh, R. M. Myers, W. E. Bunney, S. J. Watson, E. G. Jones, H. Akil

Research output: Contribution to journalArticle

270 Scopus citations

Abstract

In this report we describe findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions of brains from human subjects with major depressive disorder (MDD). This altered gene expression was discovered by microarray analysis of frontal cortical tissue from MDD, bipolar, and nonpsychiatric control subjects and was verified by quantitative real-time PCR analysis and, importantly, in a separate cohort of MDD subjects. Furthermore, we show, through a separate analysis of specific serotonin reuptake inhibitor (SSRI)-treated and non-SSRI-treated MDD subjects that the observed changes in expression of FGF transcripts are not secondary to drug treatment. Rather, changes in specific FGF transcripts are attenuated by SSRIs and may thus be partially responsible for the mechanism of action of these drugs. We also make available the gene-expression profile of all of the other growth factors and growth factor receptors detected in these postmortem samples.

Original languageEnglish (US)
Pages (from-to)15506-15511
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number43
DOIs
StatePublished - Oct 26 2004

ASJC Scopus subject areas

  • Genetics
  • General

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    Evans, S. J., Choudary, P. V., Neal, C. R., Li, J. Z., Vawter, M. P., Tomita, H., Lopez, J. F., Thompson, R. C., Meng, F., Stead, J. D., Walsh, D. M., Myers, R. M., Bunney, W. E., Watson, S. J., Jones, E. G., & Akil, H. (2004). Dysregulation of the fibroblast growth factor system in major depression. Proceedings of the National Academy of Sciences of the United States of America, 101(43), 15506-15511. https://doi.org/10.1073/pnas.0406788101