Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathy

L. Rachael Ryckman, Dennis J. Krahwinkel, Michael H. Sims, Robert L. Donnell, Peter F Moore, G. Diane Shelton

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Two adult Boxers were evaluated because of chronic dysphagia of several years' duration. Serum creatine kinase activity was high in both dogs, but other hematologic or serum biochemical abnormalities were not detected. Esophagraphy revealed abnormalities of the cricopharyngeal phase of swallowing in both dogs, and electromyography of the pharyngeal and laryngeal muscles revealed complex repetitive discharges, positive sharp waves, and fibrillation potentials characteristic of primary myopathy or neuropathy. Because of the severity of their condition, both dogs were euthanatized. Histologically mixed-cell infiltrates were seen in sections of the masseter and thyropharyngeal muscles. Results of indirect immunofluorescence staining for proteins associated with dystrophic myopathy were unremarkable, except for decreased staining for integrin α7. A diagnosis of chronic inflammatory myopathy was made. The clinical importance of reduced staining for integrin α7 could not be determined but was considered to be a result of the myopathy.

Original languageEnglish (US)
JournalJournal of the American Veterinary Medical Association
Volume226
Issue number9
DOIs
StatePublished - May 1 2005

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Myositis
muscular diseases
Muscular Diseases
Deglutition Disorders
Dogs
Staining and Labeling
Integrins
dogs
integrins
Pharyngeal Muscles
Laryngeal Muscles
Masseter Muscle
Electromyography
Indirect Fluorescent Antibody Technique
Deglutition
Creatine Kinase
Serum
Boxer (dog breed)
muscles
electromyography

ASJC Scopus subject areas

  • veterinary(all)

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Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathy. / Ryckman, L. Rachael; Krahwinkel, Dennis J.; Sims, Michael H.; Donnell, Robert L.; Moore, Peter F; Shelton, G. Diane.

In: Journal of the American Veterinary Medical Association, Vol. 226, No. 9, 01.05.2005.

Research output: Contribution to journalArticle

Ryckman, L. Rachael ; Krahwinkel, Dennis J. ; Sims, Michael H. ; Donnell, Robert L. ; Moore, Peter F ; Shelton, G. Diane. / Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathy. In: Journal of the American Veterinary Medical Association. 2005 ; Vol. 226, No. 9.
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