Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathy

L. Rachael Ryckman, Dennis J. Krahwinkel, Michael H. Sims, Robert L. Donnell, Peter F Moore, G. Diane Shelton

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Two adult Boxers were evaluated because of chronic dysphagia of several years' duration. Serum creatine kinase activity was high in both dogs, but other hematologic or serum biochemical abnormalities were not detected. Esophagraphy revealed abnormalities of the cricopharyngeal phase of swallowing in both dogs, and electromyography of the pharyngeal and laryngeal muscles revealed complex repetitive discharges, positive sharp waves, and fibrillation potentials characteristic of primary myopathy or neuropathy. Because of the severity of their condition, both dogs were euthanatized. Histologically mixed-cell infiltrates were seen in sections of the masseter and thyropharyngeal muscles. Results of indirect immunofluorescence staining for proteins associated with dystrophic myopathy were unremarkable, except for decreased staining for integrin α7. A diagnosis of chronic inflammatory myopathy was made. The clinical importance of reduced staining for integrin α7 could not be determined but was considered to be a result of the myopathy.

Original languageEnglish (US)
JournalJournal of the American Veterinary Medical Association
Issue number9
StatePublished - May 1 2005

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathy'. Together they form a unique fingerprint.

Cite this