Dysmyelination in Chow Chow dogs: Further studies in older dogs

M. Vandevelde, K. G. Braund, P. J. Luttgen, Robert Higgins

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The ultrastructure of myelin deficiency in Chow Chow dogs was studied in the spinal cord of a 15-month-old and a 3-year-old animal. It was found that myelination progresses with age in these dogs but is still deficient at the age of 3 years. The findings included axons with thin or uncompacted myelin sheaths, separated from each other by massive astrocytosis, and bizarre myelin formations. Normal numbers of morphologically normal oligodendrocytes were present in the myelin-deficient areas. The disease in these Chow Chow dogs consists of a strongly retarded myelination which is possibly due to a dysfunction or delay in glial maturation.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalActa Neuropathologica
Issue number2
StatePublished - Jun 1 1981
Externally publishedYes


  • Canine CNS
  • Electron microscopy
  • Hypomyelinogenesis
  • Myelination

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology


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