Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction

Yael Litvak, Mariana X. Byndloss, Renee M Tsolis, Andreas J Baumler

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

A balanced gut microbiota is important for health, but the mechanisms maintaining homeostasis are incompletely understood. Anaerobiosis of the healthy colon drives the composition of the gut microbiota towards a dominance of obligate anaerobes, while dysbiosis is often associated with a sustained increase in the abundance of facultative anaerobic Proteobacteria, indicative of a disruption in anaerobiosis. The colonic epithelium is hypoxic, but intestinal inflammation or antibiotic treatment increases epithelial oxygenation in the colon, thereby disrupting anaerobiosis to drive a dysbiotic expansion of facultative anaerobic Proteobacteria through aerobic respiration. These observations suggest a dysbiotic expansion of Proteobacteria is a potential diagnostic microbial signature of epithelial dysfunction, a hypothesis that could spawn novel preventative or therapeutic strategies for a broad spectrum of human diseases.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCurrent Opinion in Microbiology
Volume39
DOIs
StatePublished - Oct 1 2017

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ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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