Dysbiosis in the inflamed intestine

Chance favors the prepared microbe

Sebastian E. Winter, Andreas J Baumler

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The bacterial microbiota of the human large bowel is a complex ecosystem consisting of several hundred, mostly anaerobic, species. To maintain colonization of the gut lumen and maximize growth in the presence of nutritional competitors, highly diverse metabolic pathways have evolved, with each microbe utilizing a different "winning strategy" for nutrient acquisition and utilization. Conditions and diseases leading to intestinal inflammation are accompanied by a severe disruption the microbiota composition characterized by an expansion of facultative anaerobic Enterobacteriaceae. Here, we review evidence that the local inflammatory response creates a unique nutritional environment that is conducive to a bloom of bacterial species whose genomes encode the capability of utilizing inflammationderived nutrients.

Original languageEnglish (US)
Pages (from-to)71-73
Number of pages3
JournalGut Microbes
Volume5
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Dysbiosis
Microbiota
Intestines
Enterobacteriaceae
Metabolic Networks and Pathways
Ecosystem
Genome
Inflammation
Food
Growth

Keywords

  • Dysbiosis
  • Enteric pathogens
  • Enterobacteriaceae
  • Inflammatory bowel disease
  • Irritable bowel syndrome
  • Necrotizing enterocolitis

ASJC Scopus subject areas

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Dysbiosis in the inflamed intestine : Chance favors the prepared microbe. / Winter, Sebastian E.; Baumler, Andreas J.

In: Gut Microbes, Vol. 5, No. 1, 2014, p. 71-73.

Research output: Contribution to journalArticle

@article{6458b0c1468f4a99959ad65c68594eef,
title = "Dysbiosis in the inflamed intestine: Chance favors the prepared microbe",
abstract = "The bacterial microbiota of the human large bowel is a complex ecosystem consisting of several hundred, mostly anaerobic, species. To maintain colonization of the gut lumen and maximize growth in the presence of nutritional competitors, highly diverse metabolic pathways have evolved, with each microbe utilizing a different {"}winning strategy{"} for nutrient acquisition and utilization. Conditions and diseases leading to intestinal inflammation are accompanied by a severe disruption the microbiota composition characterized by an expansion of facultative anaerobic Enterobacteriaceae. Here, we review evidence that the local inflammatory response creates a unique nutritional environment that is conducive to a bloom of bacterial species whose genomes encode the capability of utilizing inflammationderived nutrients.",
keywords = "Dysbiosis, Enteric pathogens, Enterobacteriaceae, Inflammatory bowel disease, Irritable bowel syndrome, Necrotizing enterocolitis",
author = "Winter, {Sebastian E.} and Baumler, {Andreas J}",
year = "2014",
doi = "10.4161/gmic.27129",
language = "English (US)",
volume = "5",
pages = "71--73",
journal = "Gut Microbes",
issn = "1949-0976",
publisher = "Landes Bioscience",
number = "1",

}

TY - JOUR

T1 - Dysbiosis in the inflamed intestine

T2 - Chance favors the prepared microbe

AU - Winter, Sebastian E.

AU - Baumler, Andreas J

PY - 2014

Y1 - 2014

N2 - The bacterial microbiota of the human large bowel is a complex ecosystem consisting of several hundred, mostly anaerobic, species. To maintain colonization of the gut lumen and maximize growth in the presence of nutritional competitors, highly diverse metabolic pathways have evolved, with each microbe utilizing a different "winning strategy" for nutrient acquisition and utilization. Conditions and diseases leading to intestinal inflammation are accompanied by a severe disruption the microbiota composition characterized by an expansion of facultative anaerobic Enterobacteriaceae. Here, we review evidence that the local inflammatory response creates a unique nutritional environment that is conducive to a bloom of bacterial species whose genomes encode the capability of utilizing inflammationderived nutrients.

AB - The bacterial microbiota of the human large bowel is a complex ecosystem consisting of several hundred, mostly anaerobic, species. To maintain colonization of the gut lumen and maximize growth in the presence of nutritional competitors, highly diverse metabolic pathways have evolved, with each microbe utilizing a different "winning strategy" for nutrient acquisition and utilization. Conditions and diseases leading to intestinal inflammation are accompanied by a severe disruption the microbiota composition characterized by an expansion of facultative anaerobic Enterobacteriaceae. Here, we review evidence that the local inflammatory response creates a unique nutritional environment that is conducive to a bloom of bacterial species whose genomes encode the capability of utilizing inflammationderived nutrients.

KW - Dysbiosis

KW - Enteric pathogens

KW - Enterobacteriaceae

KW - Inflammatory bowel disease

KW - Irritable bowel syndrome

KW - Necrotizing enterocolitis

UR - http://www.scopus.com/inward/record.url?scp=84914112702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84914112702&partnerID=8YFLogxK

U2 - 10.4161/gmic.27129

DO - 10.4161/gmic.27129

M3 - Article

VL - 5

SP - 71

EP - 73

JO - Gut Microbes

JF - Gut Microbes

SN - 1949-0976

IS - 1

ER -