Dysbiosis-A consequence of Paneth cell dysfunction

Nita H. Salzman, Charles L Bevins

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

The complex community of colonizing microbes inhabiting the mucosal surfaces of mammals is vital to homeostasis and normal physiology in the host. When the composition of this microbiota is unfavorably altered, termed dysbiosis, the host is rendered more susceptible to a variety of chronic diseases. In the mammalian small intestine, specialized secretory epithelial cells, named Paneth cells, produce a variety of secreted antimicrobial peptides that fundamentally influence the composition of the microbiota. Recent investigations have identified numerous genetic and environmental factors that can disrupt normal Paneth cell function, resulting in compromised antimicrobial peptide secretion and consequent dysbiosis. These findings suggest that Paneth cell dysfunction should be considered a common cause of dysbiosis.

Original languageEnglish (US)
Pages (from-to)334-341
Number of pages8
JournalSeminars in Immunology
Volume25
Issue number5
DOIs
StatePublished - Nov 30 2013

Keywords

  • Antimicrobial peptides
  • Defensins
  • Dysbiosis
  • Microbiota
  • Paneth cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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