Dynamics of ultrasound contrast agents within rat cecum vessels

Shengping Qin, Charles F. Caskey, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A theoretical model was established to study interaction between ultrasound contrast agents (UCAs, called microbubbles) and compliant microvessels. The predicted microbubble expansion and vessel wall displacement are in good agreement with the ex vivo experimental results using the rat cecum vessels for ultrasound with a center frequency of IMHz and a PRP (peak rarefactional pressure) of 800kPa. We demonstrate that compared to the bubble oscillation within an infinite liquid or within a 200-micron tube, bubble maximum expansion within the small vessels is substantially reduced. With two-cycle 1 MHz, 0.8 MPa PRP ultrasound, the relative expansion of the shelled microbubbles with a diameter of 4 and 7.2-μm estimated by the Rayleigh-Plesset equation is 4.1 and 3.0, respectively, while within a 14-μm vessel, we observed that the bubble expansion was 2.6 and 1.3-fold, respectively. Our model predicted that the corresponding relative expansion is 2.6 and 1.8, respectively. With 0.8 MPa PRP, 1 MHZ ultrasound, a 4 pm bubble within a 25 μm vessel can displace the vessel wall up to 2 microns and induce a circumferential stress near 36kPa.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
Pages1981-1984
Number of pages4
DOIs
Publication statusPublished - 2007
Event2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States
Duration: Oct 28 2007Oct 31 2007

Other

Other2007 IEEE Ultrasonics Symposium, IUS
CountryUnited States
CityNew York, NY
Period10/28/0710/31/07

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Keywords

  • Microbubbles
  • Rat cecum vessel
  • Ultrasound contrast agents
  • Vessel deformation

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Qin, S., Caskey, C. F., & Ferrara, K. W. (2007). Dynamics of ultrasound contrast agents within rat cecum vessels. In Proceedings - IEEE Ultrasonics Symposium (pp. 1981-1984). [4410071] https://doi.org/10.1109/ULTSYM.2007.498