Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging

Anne M. Findlay, Josiah B. Ambrose, Deborah Cahn-Weiner, John F. Houde, Susanne Honma, Leighton B.N. Hinkley, Mitchel S. Berger, Srikantan S. Nagarajan, Heidi E. Kirsch

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Objective: The goal of the current study was to examine the dynamics of language lateralization using magnetoencephalographic (MEG) imaging, to determine the sensitivity and specificity of MEG imaging, and to determine whether MEG imaging can become a viable alternative to the intracarotid amobarbital procedure (IAP), the current gold standard for preoperative language lateralization in neurosurgical candidates. Methods: MEG was recorded during an auditory verb generation task and imaging analysis of oscillatory activity was initially performed in 21 subjects with epilepsy, brain tumor, or arteriovenous malformation who had undergone IAP and MEG. Time windows and brain regions of interest that best discriminated between IAP-determined left or right dominance for language were identified. Parameters derived in the retrospective analysis were applied to a prospective cohort of 14 patients and healthy controls. Results: Power decreases in the beta frequency band were consistently observed following auditory stimulation in inferior frontal, superior temporal, and parietal cortices; similar power decreases were also seen in inferior frontal cortex prior to and during overt verb generation. Language lateralization was clearly observed to be a dynamic process that is bilateral for several hundred milliseconds during periods of auditory perception and overt speech production. Correlation with the IAP was seen in 13 of 14 (93%) prospective patients, with the test demonstrating a sensitivity of 100% and specificity of 92%. Interpretation: Our results demonstrate excellent correlation between MEG imaging findings and the IAP for language lateralization, and provide new insights into the spatiotemporal dynamics of cortical speech processing.

Original languageEnglish (US)
Pages (from-to)668-686
Number of pages19
JournalAnnals of Neurology
Volume71
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

Fingerprint

Amobarbital
Language
Auditory Perception
Acoustic Stimulation
Sensitivity and Specificity
Parietal Lobe
Arteriovenous Malformations
Frontal Lobe
Temporal Lobe
Brain Neoplasms
Epilepsy
Brain

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Findlay, A. M., Ambrose, J. B., Cahn-Weiner, D., Houde, J. F., Honma, S., Hinkley, L. B. N., ... Kirsch, H. E. (2012). Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging. Annals of Neurology, 71(5), 668-686. https://doi.org/10.1002/ana.23530

Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging. / Findlay, Anne M.; Ambrose, Josiah B.; Cahn-Weiner, Deborah; Houde, John F.; Honma, Susanne; Hinkley, Leighton B.N.; Berger, Mitchel S.; Nagarajan, Srikantan S.; Kirsch, Heidi E.

In: Annals of Neurology, Vol. 71, No. 5, 01.05.2012, p. 668-686.

Research output: Contribution to journalArticle

Findlay, AM, Ambrose, JB, Cahn-Weiner, D, Houde, JF, Honma, S, Hinkley, LBN, Berger, MS, Nagarajan, SS & Kirsch, HE 2012, 'Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging', Annals of Neurology, vol. 71, no. 5, pp. 668-686. https://doi.org/10.1002/ana.23530
Findlay, Anne M. ; Ambrose, Josiah B. ; Cahn-Weiner, Deborah ; Houde, John F. ; Honma, Susanne ; Hinkley, Leighton B.N. ; Berger, Mitchel S. ; Nagarajan, Srikantan S. ; Kirsch, Heidi E. / Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging. In: Annals of Neurology. 2012 ; Vol. 71, No. 5. pp. 668-686.
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