Dynamics of cyclic GMP synthesis in retinal rods

Marie E Burns, Ana Mendez, Jeannie Chen, Denis A. Baylor

Research output: Contribution to journalArticlepeer-review

174 Scopus citations


In retinal rods, Ca2+ exerts negative feedback control on cGMP synthesis by guanylate cyclase (GC). This feedback loop was disrupted in mouse rods lacking guanylate cyclase activating proteins GCAP1 and GCAP2 (GCAPs-/-). Comparison of the behavior of wild-type and GCAPs-/- rods allowed us to investigate the role of the feedback loop in normal rod function. We have found that regulation of GC is apparently the only Ca2+ feedback loop operating during the single photon response. Analysis of the rods' light responses and cellular dark noise suggests that GC normally responds to light-driven changes in [Ca2+] rapidly and highly cooperatively. Rapid feedback to GC speeds the rod's temporal responsiveness and improves its signal-to-noise ratio by minimizing fluctuations in cGMP.

Original languageEnglish (US)
Pages (from-to)81-91
Number of pages11
Issue number1
StatePublished - Sep 26 2002

ASJC Scopus subject areas

  • Neuroscience(all)


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