Dynamics of cyclic GMP synthesis in retinal rods

Marie E Burns, Ana Mendez, Jeannie Chen, Denis A. Baylor

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

In retinal rods, Ca2+ exerts negative feedback control on cGMP synthesis by guanylate cyclase (GC). This feedback loop was disrupted in mouse rods lacking guanylate cyclase activating proteins GCAP1 and GCAP2 (GCAPs-/-). Comparison of the behavior of wild-type and GCAPs-/- rods allowed us to investigate the role of the feedback loop in normal rod function. We have found that regulation of GC is apparently the only Ca2+ feedback loop operating during the single photon response. Analysis of the rods' light responses and cellular dark noise suggests that GC normally responds to light-driven changes in [Ca2+] rapidly and highly cooperatively. Rapid feedback to GC speeds the rod's temporal responsiveness and improves its signal-to-noise ratio by minimizing fluctuations in cGMP.

Original languageEnglish (US)
Pages (from-to)81-91
Number of pages11
JournalNeuron
Volume36
Issue number1
DOIs
StatePublished - Sep 26 2002

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Retinal Rod Photoreceptor Cells
Cyclic GMP
Guanylate Cyclase
Guanylate Cyclase-Activating Proteins
Light
Signal-To-Noise Ratio
Photons
Noise

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dynamics of cyclic GMP synthesis in retinal rods. / Burns, Marie E; Mendez, Ana; Chen, Jeannie; Baylor, Denis A.

In: Neuron, Vol. 36, No. 1, 26.09.2002, p. 81-91.

Research output: Contribution to journalArticle

Burns, ME, Mendez, A, Chen, J & Baylor, DA 2002, 'Dynamics of cyclic GMP synthesis in retinal rods', Neuron, vol. 36, no. 1, pp. 81-91. https://doi.org/10.1016/S0896-6273(02)00911-X
Burns, Marie E ; Mendez, Ana ; Chen, Jeannie ; Baylor, Denis A. / Dynamics of cyclic GMP synthesis in retinal rods. In: Neuron. 2002 ; Vol. 36, No. 1. pp. 81-91.
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