Dynamic properties of thalamic neurons for vision

Henry J. Alitto, William Martin Usrey

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A striking property of neurons in the lateral geniculate nucleus (LGN) of the thalamus is the ability to dynamically filter and transform the temporal structure of their retinal spike input. In particular, LGN neurons respond to visual stimuli with either burst spike responses or tonic spike responses. While much is known from in vitro studies about the cellular mechanisms that underlie burst and tonic spikes, relatively little is known about the sensory stimuli that evoke these two categories of spikes. This review examines recent progress that has been made towards understanding the spatiotemporal properties of visual stimuli that evoke burst and tonic spikes. Using white-noise stimuli and reverse-correlation analysis, results show that burst and tonic spikes carry similar, but distinct, information to cortex. Compared to tonic spikes, burst spikes (1) occur with a shorter latency between stimulus and response, (2) have a greater dependence on stimuli with transitions from suppressive to preferred states, and (3) prefer stimuli that provide increased drive to the receptive field center and even greater increased drive to the receptive field surround. These results are discussed with an emphasis placed on relating the cellular constraints for burst and tonic activity with the functional properties of the early visual pathway during sensory processing.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalProgress in Brain Research
Volume149
DOIs
StatePublished - 2005

Fingerprint

Geniculate Bodies
Lateral Thalamic Nuclei
Neurons
Aptitude
Visual Pathways
Drive
In Vitro Techniques

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dynamic properties of thalamic neurons for vision. / Alitto, Henry J.; Usrey, William Martin.

In: Progress in Brain Research, Vol. 149, 2005, p. 83-90.

Research output: Contribution to journalArticle

Alitto, Henry J. ; Usrey, William Martin. / Dynamic properties of thalamic neurons for vision. In: Progress in Brain Research. 2005 ; Vol. 149. pp. 83-90.
@article{bf85e0b5db884250962a1aa08616155a,
title = "Dynamic properties of thalamic neurons for vision",
abstract = "A striking property of neurons in the lateral geniculate nucleus (LGN) of the thalamus is the ability to dynamically filter and transform the temporal structure of their retinal spike input. In particular, LGN neurons respond to visual stimuli with either burst spike responses or tonic spike responses. While much is known from in vitro studies about the cellular mechanisms that underlie burst and tonic spikes, relatively little is known about the sensory stimuli that evoke these two categories of spikes. This review examines recent progress that has been made towards understanding the spatiotemporal properties of visual stimuli that evoke burst and tonic spikes. Using white-noise stimuli and reverse-correlation analysis, results show that burst and tonic spikes carry similar, but distinct, information to cortex. Compared to tonic spikes, burst spikes (1) occur with a shorter latency between stimulus and response, (2) have a greater dependence on stimuli with transitions from suppressive to preferred states, and (3) prefer stimuli that provide increased drive to the receptive field center and even greater increased drive to the receptive field surround. These results are discussed with an emphasis placed on relating the cellular constraints for burst and tonic activity with the functional properties of the early visual pathway during sensory processing.",
author = "Alitto, {Henry J.} and Usrey, {William Martin}",
year = "2005",
doi = "10.1016/S0079-6123(05)49007-X",
language = "English (US)",
volume = "149",
pages = "83--90",
journal = "Progress in Brain Research",
issn = "0079-6123",
publisher = "Elsevier",

}

TY - JOUR

T1 - Dynamic properties of thalamic neurons for vision

AU - Alitto, Henry J.

AU - Usrey, William Martin

PY - 2005

Y1 - 2005

N2 - A striking property of neurons in the lateral geniculate nucleus (LGN) of the thalamus is the ability to dynamically filter and transform the temporal structure of their retinal spike input. In particular, LGN neurons respond to visual stimuli with either burst spike responses or tonic spike responses. While much is known from in vitro studies about the cellular mechanisms that underlie burst and tonic spikes, relatively little is known about the sensory stimuli that evoke these two categories of spikes. This review examines recent progress that has been made towards understanding the spatiotemporal properties of visual stimuli that evoke burst and tonic spikes. Using white-noise stimuli and reverse-correlation analysis, results show that burst and tonic spikes carry similar, but distinct, information to cortex. Compared to tonic spikes, burst spikes (1) occur with a shorter latency between stimulus and response, (2) have a greater dependence on stimuli with transitions from suppressive to preferred states, and (3) prefer stimuli that provide increased drive to the receptive field center and even greater increased drive to the receptive field surround. These results are discussed with an emphasis placed on relating the cellular constraints for burst and tonic activity with the functional properties of the early visual pathway during sensory processing.

AB - A striking property of neurons in the lateral geniculate nucleus (LGN) of the thalamus is the ability to dynamically filter and transform the temporal structure of their retinal spike input. In particular, LGN neurons respond to visual stimuli with either burst spike responses or tonic spike responses. While much is known from in vitro studies about the cellular mechanisms that underlie burst and tonic spikes, relatively little is known about the sensory stimuli that evoke these two categories of spikes. This review examines recent progress that has been made towards understanding the spatiotemporal properties of visual stimuli that evoke burst and tonic spikes. Using white-noise stimuli and reverse-correlation analysis, results show that burst and tonic spikes carry similar, but distinct, information to cortex. Compared to tonic spikes, burst spikes (1) occur with a shorter latency between stimulus and response, (2) have a greater dependence on stimuli with transitions from suppressive to preferred states, and (3) prefer stimuli that provide increased drive to the receptive field center and even greater increased drive to the receptive field surround. These results are discussed with an emphasis placed on relating the cellular constraints for burst and tonic activity with the functional properties of the early visual pathway during sensory processing.

UR - http://www.scopus.com/inward/record.url?scp=26844448718&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26844448718&partnerID=8YFLogxK

U2 - 10.1016/S0079-6123(05)49007-X

DO - 10.1016/S0079-6123(05)49007-X

M3 - Article

C2 - 16226578

AN - SCOPUS:26844448718

VL - 149

SP - 83

EP - 90

JO - Progress in Brain Research

JF - Progress in Brain Research

SN - 0079-6123

ER -