Dynamic MRI of Grid-Tagged Hyperpolarized Helium-3 for the Assessment of Lung Motion During Breathing

Jing Cai, Ke Sheng, Stanley H Benedict, Paul W. Read, James M. Larner, John P. Mugler, Eduard E. de Lange, Gordon D. Cates, G. Wilson Miller

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: To develop a dynamic magnetic resonance imaging (MRI) tagging technique using hyperpolarized helium-3 (HP He-3) to track lung motion. Methods and Materials: An accelerated non-Cartesian k-space trajectory was used to gain acquisition speed, at the cost of introducing image artifacts, providing a viable strategy for obtaining whole-lung coverage with adequate temporal resolution. Multiple-slice two-dimensional dynamic images of the lung were obtained in three healthy subjects after inhaling He-3 gas polarized to 35%-40%. Displacement, strain, and ventilation maps were computed from the observed motion of the grid peaks. Results: Both temporal and spatial variations of pulmonary mechanics were observed in normal subjects, including shear motion between different lobes of the same lung. Conclusion: These initial results suggest that dynamic imaging of grid-tagged hyperpolarized magnetization may potentially be a powerful tool for observing and quantifying pulmonary biomechanics on a regional basis and for assessing, validating, and improving lung deformable image registration algorithms.

Original languageEnglish (US)
Pages (from-to)276-284
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Volume75
Issue number1
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

Fingerprint

Helium
helium isotopes
breathing
lungs
magnetic resonance
Respiration
grids
Magnetic Resonance Imaging
Lung
biodynamics
ventilation
temporal resolution
lobes
marking
artifacts
acquisition
trajectories
Mechanics
Biomechanical Phenomena
shear

Keywords

  • Deformable image registration
  • Dynamic MRI
  • Hyperpolarized gas
  • Lung motion

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Dynamic MRI of Grid-Tagged Hyperpolarized Helium-3 for the Assessment of Lung Motion During Breathing. / Cai, Jing; Sheng, Ke; Benedict, Stanley H; Read, Paul W.; Larner, James M.; Mugler, John P.; de Lange, Eduard E.; Cates, Gordon D.; Miller, G. Wilson.

In: International Journal of Radiation Oncology Biology Physics, Vol. 75, No. 1, 01.09.2009, p. 276-284.

Research output: Contribution to journalArticle

Cai, Jing ; Sheng, Ke ; Benedict, Stanley H ; Read, Paul W. ; Larner, James M. ; Mugler, John P. ; de Lange, Eduard E. ; Cates, Gordon D. ; Miller, G. Wilson. / Dynamic MRI of Grid-Tagged Hyperpolarized Helium-3 for the Assessment of Lung Motion During Breathing. In: International Journal of Radiation Oncology Biology Physics. 2009 ; Vol. 75, No. 1. pp. 276-284.
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