Dynamic lung mechanics in late-stage emphysema before and after lung volume reduction surgery

A. Cortney Henderson, Edward P. Ingenito, Edgardo Salcedo, Marilyn L. Moy, John J. Reilly, Kenneth R. Lutchen

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

This study evaluated the effects of lung volume reduction surgery (LVRS) on the heterogeneity of lung function in awake, late-stage emphysema patients with measurements taken before and after full recovery from LVRS. We assessed standard clinical measures of lung function and functional heterogeneity in six awake, late-stage emphysema patients before and 6 months after LVRS. Functional heterogeneity was quantified by measuring dynamic inspiratory resistance (RL insp) and elastance (EL insp) over a frequency range that included normal breathing (∼0.33-8 Hz). Since LVRS involves targeted resection of emphysematous regions of the lung, we hypothesized that emphysema patients would be functionally more homogeneous post-LVRS. We also compared our measures of functional heterogeneity with indices of anatomic heterogeneity and severity using high-resolution computed tomography (HRCT). After LVRS, 6 min walk distance increased by 22% (940 ± 91 versus 1158 ± 299, p = 0.031) and recoil pressure at TLC increased (9.0 ± 2.0 versus 14 ± 5, p = 0.031), but changes in RL insp and EL insp varied greatly between subjects. A measure of anatomic severity quantified using HRCT positively correlated with airway resistance (rs = 0.89, p = 0.048). These results suggest that subjects with more severe disease as assessed by HRCT criteria had reduced overall effective airway caliber consequent to active airway constriction, reduced parenchymal tethering, and/or loss of parallel lung units. Furthermore, LVRS may not necessarily improve lung function via a substantial reduction in mechanical heterogeneity.

Original languageEnglish (US)
Pages (from-to)234-242
Number of pages9
JournalRespiratory Physiology and Neurobiology
Volume155
Issue number3
DOIs
StatePublished - Mar 15 2007
Externally publishedYes

Keywords

  • Chronic obstructive pulmonary disease
  • Heterogeneity
  • Inspiratory lung elastance
  • Inspiratory lung impedance
  • Inspiratory lung resistance

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

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