Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis

Brianne M. Bettcher, Alden L. Gross, Brandon E. Gavett, Keith F. Widaman, Evan Fletcher, N. Maritza Dowling, Rachel F. Buckley, Eider M. Arenaza-Urquijo, Laura B. Zahodne, Timothy J. Hohman, Jet M.J. Vonk, Dorene M. Rentz, Dan Mungas

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cognitive reserve is inherently a dynamic construct; however, traditional methods of estimating reserve have focused on static proxy variables. A recently proposed psychometric approach entails modeling reserve as residual cognition not explained by demographic and brain variables. In this study, we extended this approach to longitudinal measurement and examined how change in reserve relates to clinical outcomes in late life and influences the effect of brain atrophy on cognitive decline. Results indicated that cognitive reserve changes were associated with progression of clinical diagnosis. More rapid depletion of cognitive reserve was associated with faster decline in nonmemory cognitive functions, even after accounting for longitudinal brain atrophy. The effect of longitudinal brain atrophy on cognitive decline differed based on the extent to which an individual's reserve changed. Whereas depletion of reserve appeared to unmask the effects of brain atrophy on cognitive decline, maintenance of reserve buffered against the negative effects of brain atrophy. Study results highlight that changes in reserve may have important implications for individual differences in cognitive aging trajectories.

Original languageEnglish (US)
Pages (from-to)95-104
Number of pages10
JournalNeurobiology of aging
Volume83
DOIs
StatePublished - Nov 2019

Fingerprint

Cognitive Reserve
Cognition
Atrophy
Brain
Proxy
Psychometrics
Individuality
Maintenance
Demography

Keywords

  • Aging
  • Cognitive decline
  • Cognitive reserve
  • Gray matter change
  • Hippocampus
  • MRI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Dynamic change of cognitive reserve : associations with changes in brain, cognition, and diagnosis. / Bettcher, Brianne M.; Gross, Alden L.; Gavett, Brandon E.; Widaman, Keith F.; Fletcher, Evan; Dowling, N. Maritza; Buckley, Rachel F.; Arenaza-Urquijo, Eider M.; Zahodne, Laura B.; Hohman, Timothy J.; Vonk, Jet M.J.; Rentz, Dorene M.; Mungas, Dan.

In: Neurobiology of aging, Vol. 83, 11.2019, p. 95-104.

Research output: Contribution to journalArticle

Bettcher, BM, Gross, AL, Gavett, BE, Widaman, KF, Fletcher, E, Dowling, NM, Buckley, RF, Arenaza-Urquijo, EM, Zahodne, LB, Hohman, TJ, Vonk, JMJ, Rentz, DM & Mungas, D 2019, 'Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis', Neurobiology of aging, vol. 83, pp. 95-104. https://doi.org/10.1016/j.neurobiolaging.2019.08.016
Bettcher, Brianne M. ; Gross, Alden L. ; Gavett, Brandon E. ; Widaman, Keith F. ; Fletcher, Evan ; Dowling, N. Maritza ; Buckley, Rachel F. ; Arenaza-Urquijo, Eider M. ; Zahodne, Laura B. ; Hohman, Timothy J. ; Vonk, Jet M.J. ; Rentz, Dorene M. ; Mungas, Dan. / Dynamic change of cognitive reserve : associations with changes in brain, cognition, and diagnosis. In: Neurobiology of aging. 2019 ; Vol. 83. pp. 95-104.
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