Dynamic aspects of CNS synapse formation

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

The mammalian central nervous system (CNS) requires the proper formation of exquisitely precise circuits to function correctly. These neuronal circuits are assembled during development by the formation of synaptic connections between thousands of differentiating neurons. Proper synapse formation during childhood provides the substrate for cognition, whereas improper formation or function of these synapses leads to neurodevelopmental disorders, including mental retardation and autism. Recent work has begun to identify some of the early cellular events in synapse formation as well as the molecular signals that initiate this process. However, despite the wealth of information published on this topic in the past few years, some of the most fundamental questions about how, whether, and where glutamatergic synapses form in the mammalian CNS remain unanswered. This review focuses on the dynamic aspects of the early cellular and molecular events in the initial assembly of glutamatergic synapses in the mammalian CNS.

Original languageEnglish (US)
Pages (from-to)425-450
Number of pages26
JournalAnnual Review of Neuroscience
Volume30
DOIs
StatePublished - 2007

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Synapses
Central Nervous System
Autistic Disorder
Intellectual Disability
Cognition
Neurons

Keywords

  • Axon
  • Cell adhesion
  • Dendrite
  • Development
  • Glutamate receptors
  • Vesicle trafficking

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dynamic aspects of CNS synapse formation. / Usrey, A Kimberley.

In: Annual Review of Neuroscience, Vol. 30, 2007, p. 425-450.

Research output: Contribution to journalArticle

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