Dust generator for inhalation studies with limited amounts of archived particulate matter

Stephen V. Teague, John M. Veranth, Ann E. Aust, Kent E Pinkerton

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A novel design for a dry-aerosol generator that efficiently produces a well-dispersed dust suspension using small quantities of a PM 2.5-enriched powder sample is described. The motivation to develop a highly efficient dry-aerosol particle generator was to facilitate collaborative projects that combine in vitro cell culture experiments and multiday inhalation exposures using a single batch of well-characterized particles. Premixing of the test particles with larger diameter glass beads permits delivery of aerosol concentrations from 100-1000 μg/m3 to an exposure chamber using only milligram quantities of the test powder per hour. Examination of exposure chamber filter samples by scanning electron microscopy. showed well-dispersed particles of the test powder free of glass spheres or fragments. Data are presented from experiments using coal fly ash as the test powder to illustrate the system performance.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalAerosol Science and Technology
Volume39
Issue number2
DOIs
StatePublished - Feb 2005

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Mechanical Engineering

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