Duration of neurofibrillary changes in the hippocampal pyramidal neurons

Matthew Bobinski, Jerzy Wegiel, Michal Tarnawski, Margaret Bobinski, Mony J. De Leon, Barry Reisberg, Douglas C. Miller, Henryk M. Wisniewski

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyms of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.

Original languageEnglish (US)
Pages (from-to)156-158
Number of pages3
JournalBrain Research
Issue number1
StatePublished - Jul 13 1998
Externally publishedYes


  • Alzheimer disease
  • Hippocampus
  • Neurofibrillary pathology
  • Neurofibrillary staging
  • Stereology

ASJC Scopus subject areas

  • Neuroscience(all)


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