Duration of neurofibrillary changes in the hippocampal pyramidal neurons

Matthew Bobinski; Jerzy Wegiel; Michal Tarnawski; Margaret Bobinski; Mony J. De Leon; Barry Reisberg; Douglas C. Miller; Henryk M. Wisniewski

doi:10.1016/S0006-8993(98)00441-7

Duration of neurofibrillary changes in the hippocampal pyramidal neurons

Matthew Bobinski, Jerzy Wegiel, Michal Tarnawski, Margaret Bobinski, Mony J. De Leon, Barry Reisberg, Douglas C. Miller, Henryk M. Wisniewski

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyms of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.

Original language	English (US)
Pages (from-to)	156-158
Number of pages	3
Journal	Brain Research
Volume	799
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(98)00441-7
State	Published - Jul 13 1998
Externally published	Yes

Keywords

Alzheimer disease
Hippocampus
Neurofibrillary pathology
Neurofibrillary staging
Stereology

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0006-8993(98)00441-7

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title = "Duration of neurofibrillary changes in the hippocampal pyramidal neurons",

abstract = "The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyms of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.",

keywords = "Alzheimer disease, Hippocampus, Neurofibrillary pathology, Neurofibrillary staging, Stereology",

author = "Matthew Bobinski and Jerzy Wegiel and Michal Tarnawski and Margaret Bobinski and {De Leon}, {Mony J.} and Barry Reisberg and Miller, {Douglas C.} and Wisniewski, {Henryk M.}",

year = "1998",

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T1 - Duration of neurofibrillary changes in the hippocampal pyramidal neurons

AU - Bobinski, Matthew

AU - Wegiel, Jerzy

AU - Tarnawski, Michal

AU - Bobinski, Margaret

AU - De Leon, Mony J.

AU - Reisberg, Barry

AU - Miller, Douglas C.

AU - Wisniewski, Henryk M.

PY - 1998/7/13

Y1 - 1998/7/13

N2 - The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyms of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.

AB - The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyms of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.

KW - Alzheimer disease

KW - Hippocampus

KW - Neurofibrillary pathology

KW - Neurofibrillary staging

KW - Stereology

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JO - Brain Research

JF - Brain Research

SN - 0006-8993

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ER -

Duration of neurofibrillary changes in the hippocampal pyramidal neurons

Abstract

Keywords

ASJC Scopus subject areas

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