Abstract
The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyms of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 156-158 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 799 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 13 1998 |
| Externally published | Yes |
Keywords
- Alzheimer disease
- Hippocampus
- Neurofibrillary pathology
- Neurofibrillary staging
- Stereology
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Bobinski, M., Wegiel, J., Tarnawski, M., Bobinski, M., De Leon, M. J., Reisberg, B., Miller, D. C., & Wisniewski, H. M. (1998). Duration of neurofibrillary changes in the hippocampal pyramidal neurons. Brain Research, 799(1), 156-158. https://doi.org/10.1016/S0006-8993(98)00441-7