Duration of neurofibrillary changes in the hippocampal pyramidal neurons

Matthew Bobinski; Jerzy Wegiel; Michal Tarnawski; Margaret Bobinski; Mony J. De Leon; Barry Reisberg; Douglas C. Miller; Henryk M. Wisniewski

doi:10.1016/S0006-8993(98)00441-7

Duration of neurofibrillary changes in the hippocampal pyramidal neurons

Matthew Bobinski, Jerzy Wegiel, Michal Tarnawski, Margaret Bobinski, Mony J. De Leon, Barry Reisberg, Douglas C. Miller, Henryk M. Wisniewski

Research output: Contribution to journal › Article

36 Scopus citations

Abstract

The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyms of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.

Original language	English (US)
Pages (from-to)	156-158
Number of pages	3
Journal	Brain Research
Volume	799
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(98)00441-7
State	Published - Jul 13 1998
Externally published	Yes

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Keywords

Alzheimer disease
Hippocampus
Neurofibrillary pathology
Neurofibrillary staging
Stereology

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Bobinski, M., Wegiel, J., Tarnawski, M., Bobinski, M., De Leon, M. J., Reisberg, B., Miller, D. C., & Wisniewski, H. M. (1998). Duration of neurofibrillary changes in the hippocampal pyramidal neurons. Brain Research, 799(1), 156-158. https://doi.org/10.1016/S0006-8993(98)00441-7

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AU - De Leon, Mony J.

AU - Reisberg, Barry

AU - Miller, Douglas C.

AU - Wisniewski, Henryk M.

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KW - Neurofibrillary pathology

KW - Neurofibrillary staging

KW - Stereology

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10.1016/S0006-8993(98)00441-7