Dural marginal zone lymphoma with massive amyloid deposition: Rare low-grade primary central nervous system B-cell lymphoma. Case report

Norman L. Lehman, Dikran S. Horoupian, Roger A. Warnke, Uma N. Sundram, Kendra Peterson, Griffith R. Harsh IV

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The authors report the case of a 63-year-old woman who presented with a primary dural extranodal marginal zone lymphoma (MZL) associated with massive kappa light chain amyloidosis of the meninges. Extranodal MZL is a low-grade B-cell lymphoma that may show variable degrees of plasmacytic differentiation. Like solitary plasmacytoma of soft tissue, which can also be associated with amyloid, extranodal MZL generally responds well to local therapy and has a good prognosis. It is important to distinguish these entities from high-grade primary central nervous system (CNS) B-cell lymphomas and more aggressive and/or widespread, potentially amyloidogenic conditions such as multiple myeloma, lymphoplasmacytoid lymphoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma. To the authors' knowledge this is the first reported case of dural MZL associated with massive meningeal amyloid deposition. Extranodal MZL is a rare low-grade primary CNS B-cell lymphoma that may be associated with amyloidosis. It should be considered in the differential diagnosis of CNS lymphoproliferative lesions and CNS amyloidosis.

Original languageEnglish (US)
Pages (from-to)368-372
Number of pages5
JournalJournal of Neurosurgery
Volume96
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Amyloidosis
  • B-cell lymphoma
  • Dural tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Dural marginal zone lymphoma with massive amyloid deposition: Rare low-grade primary central nervous system B-cell lymphoma. Case report'. Together they form a unique fingerprint.

Cite this