Abstract
The role of CCK in mediating neuronal activity in the brain in response to dietary carbohydrate was measured by detecting Fos immunoreactivity in response to duodenal glucose load in rats after administration of the CCK-A receptor antagonist devazepide. In adult, male Sprague-Dawley rats, infusion for 30 min of 545 mg (2.18 kcal) dextrose through a duodenal cannula induced Fos expression in the nucleus of the solitary tract (NTS), area postrema (AP), lateral division of the central nucleus of the amygdala (CeAL), and the external subnucleus of the lateral parabrachial nucleus (LPBE). Devazepide treatment (1 mg/kg) attenuated Fos expression in the NTS and AP by 81 and 78%, respectively, but not in the CeAL or LPBE. These results indicate that central neuronal activation is elicited by dietary glucose in the intestinal lumen and that activation of neurons in the NTS and AP is mediated by CCK-A receptors.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 277 |
| Issue number | 3 46-3 |
| State | Published - Sep 1999 |
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Keywords
- Area postrema
- Cholecystokinin
- Feeding
- Nucleus of the solitary tract
- Satiety
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Duodenal loading with glucose induces Fos expression in rat brain : Selective blockade by devazepide. / Wang, Lixin; Cardin, Sylvain; Martínez, Vicente; Taché, Yvette; Lloyd, Kevin C K.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 277, No. 3 46-3, 09.1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Duodenal loading with glucose induces Fos expression in rat brain
T2 - Selective blockade by devazepide
AU - Wang, Lixin
AU - Cardin, Sylvain
AU - Martínez, Vicente
AU - Taché, Yvette
AU - Lloyd, Kevin C K
PY - 1999/9
Y1 - 1999/9
N2 - The role of CCK in mediating neuronal activity in the brain in response to dietary carbohydrate was measured by detecting Fos immunoreactivity in response to duodenal glucose load in rats after administration of the CCK-A receptor antagonist devazepide. In adult, male Sprague-Dawley rats, infusion for 30 min of 545 mg (2.18 kcal) dextrose through a duodenal cannula induced Fos expression in the nucleus of the solitary tract (NTS), area postrema (AP), lateral division of the central nucleus of the amygdala (CeAL), and the external subnucleus of the lateral parabrachial nucleus (LPBE). Devazepide treatment (1 mg/kg) attenuated Fos expression in the NTS and AP by 81 and 78%, respectively, but not in the CeAL or LPBE. These results indicate that central neuronal activation is elicited by dietary glucose in the intestinal lumen and that activation of neurons in the NTS and AP is mediated by CCK-A receptors.
AB - The role of CCK in mediating neuronal activity in the brain in response to dietary carbohydrate was measured by detecting Fos immunoreactivity in response to duodenal glucose load in rats after administration of the CCK-A receptor antagonist devazepide. In adult, male Sprague-Dawley rats, infusion for 30 min of 545 mg (2.18 kcal) dextrose through a duodenal cannula induced Fos expression in the nucleus of the solitary tract (NTS), area postrema (AP), lateral division of the central nucleus of the amygdala (CeAL), and the external subnucleus of the lateral parabrachial nucleus (LPBE). Devazepide treatment (1 mg/kg) attenuated Fos expression in the NTS and AP by 81 and 78%, respectively, but not in the CeAL or LPBE. These results indicate that central neuronal activation is elicited by dietary glucose in the intestinal lumen and that activation of neurons in the NTS and AP is mediated by CCK-A receptors.
KW - Area postrema
KW - Cholecystokinin
KW - Feeding
KW - Nucleus of the solitary tract
KW - Satiety
UR - http://www.scopus.com/inward/record.url?scp=0032862555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032862555&partnerID=8YFLogxK
M3 - Article
C2 - 10484482
AN - SCOPUS:0032862555
VL - 277
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 3 46-3
ER -