Duodenal loading with glucose induces Fos expression in rat brain: Selective blockade by devazepide

Lixin Wang, Sylvain Cardin, Vicente Martínez, Yvette Taché, Kevin C K Lloyd

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The role of CCK in mediating neuronal activity in the brain in response to dietary carbohydrate was measured by detecting Fos immunoreactivity in response to duodenal glucose load in rats after administration of the CCK-A receptor antagonist devazepide. In adult, male Sprague-Dawley rats, infusion for 30 min of 545 mg (2.18 kcal) dextrose through a duodenal cannula induced Fos expression in the nucleus of the solitary tract (NTS), area postrema (AP), lateral division of the central nucleus of the amygdala (CeAL), and the external subnucleus of the lateral parabrachial nucleus (LPBE). Devazepide treatment (1 mg/kg) attenuated Fos expression in the NTS and AP by 81 and 78%, respectively, but not in the CeAL or LPBE. These results indicate that central neuronal activation is elicited by dietary glucose in the intestinal lumen and that activation of neurons in the NTS and AP is mediated by CCK-A receptors.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume277
Issue number3 46-3
StatePublished - Sep 1999

Fingerprint

Devazepide
Area Postrema
Cholecystokinin A Receptor
Glucose
Brain
Dietary Carbohydrates
Solitary Nucleus
Sprague Dawley Rats
Neurons
Parabrachial Nucleus
Central Amygdaloid Nucleus

Keywords

  • Area postrema
  • Cholecystokinin
  • Feeding
  • Nucleus of the solitary tract
  • Satiety

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Duodenal loading with glucose induces Fos expression in rat brain : Selective blockade by devazepide. / Wang, Lixin; Cardin, Sylvain; Martínez, Vicente; Taché, Yvette; Lloyd, Kevin C K.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 277, No. 3 46-3, 09.1999.

Research output: Contribution to journalArticle

@article{dacee782131a496c9cfec52b2f80ddd8,
title = "Duodenal loading with glucose induces Fos expression in rat brain: Selective blockade by devazepide",
abstract = "The role of CCK in mediating neuronal activity in the brain in response to dietary carbohydrate was measured by detecting Fos immunoreactivity in response to duodenal glucose load in rats after administration of the CCK-A receptor antagonist devazepide. In adult, male Sprague-Dawley rats, infusion for 30 min of 545 mg (2.18 kcal) dextrose through a duodenal cannula induced Fos expression in the nucleus of the solitary tract (NTS), area postrema (AP), lateral division of the central nucleus of the amygdala (CeAL), and the external subnucleus of the lateral parabrachial nucleus (LPBE). Devazepide treatment (1 mg/kg) attenuated Fos expression in the NTS and AP by 81 and 78{\%}, respectively, but not in the CeAL or LPBE. These results indicate that central neuronal activation is elicited by dietary glucose in the intestinal lumen and that activation of neurons in the NTS and AP is mediated by CCK-A receptors.",
keywords = "Area postrema, Cholecystokinin, Feeding, Nucleus of the solitary tract, Satiety",
author = "Lixin Wang and Sylvain Cardin and Vicente Mart{\'i}nez and Yvette Tach{\'e} and Lloyd, {Kevin C K}",
year = "1999",
month = "9",
language = "English (US)",
volume = "277",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "3 46-3",

}

TY - JOUR

T1 - Duodenal loading with glucose induces Fos expression in rat brain

T2 - Selective blockade by devazepide

AU - Wang, Lixin

AU - Cardin, Sylvain

AU - Martínez, Vicente

AU - Taché, Yvette

AU - Lloyd, Kevin C K

PY - 1999/9

Y1 - 1999/9

N2 - The role of CCK in mediating neuronal activity in the brain in response to dietary carbohydrate was measured by detecting Fos immunoreactivity in response to duodenal glucose load in rats after administration of the CCK-A receptor antagonist devazepide. In adult, male Sprague-Dawley rats, infusion for 30 min of 545 mg (2.18 kcal) dextrose through a duodenal cannula induced Fos expression in the nucleus of the solitary tract (NTS), area postrema (AP), lateral division of the central nucleus of the amygdala (CeAL), and the external subnucleus of the lateral parabrachial nucleus (LPBE). Devazepide treatment (1 mg/kg) attenuated Fos expression in the NTS and AP by 81 and 78%, respectively, but not in the CeAL or LPBE. These results indicate that central neuronal activation is elicited by dietary glucose in the intestinal lumen and that activation of neurons in the NTS and AP is mediated by CCK-A receptors.

AB - The role of CCK in mediating neuronal activity in the brain in response to dietary carbohydrate was measured by detecting Fos immunoreactivity in response to duodenal glucose load in rats after administration of the CCK-A receptor antagonist devazepide. In adult, male Sprague-Dawley rats, infusion for 30 min of 545 mg (2.18 kcal) dextrose through a duodenal cannula induced Fos expression in the nucleus of the solitary tract (NTS), area postrema (AP), lateral division of the central nucleus of the amygdala (CeAL), and the external subnucleus of the lateral parabrachial nucleus (LPBE). Devazepide treatment (1 mg/kg) attenuated Fos expression in the NTS and AP by 81 and 78%, respectively, but not in the CeAL or LPBE. These results indicate that central neuronal activation is elicited by dietary glucose in the intestinal lumen and that activation of neurons in the NTS and AP is mediated by CCK-A receptors.

KW - Area postrema

KW - Cholecystokinin

KW - Feeding

KW - Nucleus of the solitary tract

KW - Satiety

UR - http://www.scopus.com/inward/record.url?scp=0032862555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032862555&partnerID=8YFLogxK

M3 - Article

C2 - 10484482

AN - SCOPUS:0032862555

VL - 277

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 3 46-3

ER -