Duodenal loading with glucose induces Fos expression in rat brain: Selective blockade by devazepide

Lixin Wang, Sylvain Cardin, Vicente Martínez, Yvette Taché, Kevin C K Lloyd

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The role of CCK in mediating neuronal activity in the brain in response to dietary carbohydrate was measured by detecting Fos immunoreactivity in response to duodenal glucose load in rats after administration of the CCK-A receptor antagonist devazepide. In adult, male Sprague-Dawley rats, infusion for 30 min of 545 mg (2.18 kcal) dextrose through a duodenal cannula induced Fos expression in the nucleus of the solitary tract (NTS), area postrema (AP), lateral division of the central nucleus of the amygdala (CeAL), and the external subnucleus of the lateral parabrachial nucleus (LPBE). Devazepide treatment (1 mg/kg) attenuated Fos expression in the NTS and AP by 81 and 78%, respectively, but not in the CeAL or LPBE. These results indicate that central neuronal activation is elicited by dietary glucose in the intestinal lumen and that activation of neurons in the NTS and AP is mediated by CCK-A receptors.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume277
Issue number3 46-3
StatePublished - Sep 1999

Keywords

  • Area postrema
  • Cholecystokinin
  • Feeding
  • Nucleus of the solitary tract
  • Satiety

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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