Ductular expression of autoantigens in primary biliary cirrhosis

Ruth Joplin, M. Eric Gershwin

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The role of biliary epithelial cell (BEC) antigens in immune recognition and damage of biliary epithelium in primary biliary cirrhosis (PBC) is unknown. The major autoantigen in PBC (the mitochondrial enzyme pyruvate dehydrogenase dihydrolipoamide acetyltransferase [PDC-E2]) is abnormally distributed in the biliary epithelium of patients with PBC relative to controls. The antigen is not only present in mitochondria but also associated with the BEC plasma membrane. This atypical distribution of PDC-E2 is present both in early (stages I-II) and advanced (stages III-IV) disease, suggesting a role for the antigen in progression and/or etiology of PBC. The identity of the plasma membrane antigen remains unknown, but there is evidence to suggest that it is an antigen that cross reacts with antibodies to PDC-E2. Use of BEC purified from human liver may help in deciphering the possible importance of BEC plasma membrane antigens in immune recognition and toxicity toward BEC in PBC.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalSeminars in Liver Disease
Volume17
Issue number2
StatePublished - May 1997

Keywords

  • Biliary epithelium
  • Mitochondria
  • Pyruvate dehydrogenase complex

ASJC Scopus subject areas

  • Hepatology

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