Hyperbilirubinemia and a delayed plasma clearance of sulfobromophthalein was observed in neonatal mutant lambs possessing a syndrome similar to Dubin-Johnson syndrome in man. Characteristic discoloration of the liver due to hepatocellular pigmentation was not discernible at birth when examined by electron and light microscopy. The livers of 2 mutants were first observed to be grossly discolored owing to pigment accumulation at 7 and 11 weeks of age, respectively. The brownish-black pigment was primarily found in the pericanalicular dense bodies of centrilobular hepatocytes.
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