Dubin-Johnson syndrome in immature sheep

C. E. Cornelius, Bennie Osburn, R. R. Gronwall, G. H. Cardinet

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Hyperbilirubinemia and a delayed plasma clearance of sulfobromophthalein was observed in neonatal mutant lambs possessing a syndrome similar to Dubin-Johnson syndrome in man. Characteristic discoloration of the liver due to hepatocellular pigmentation was not discernible at birth when examined by electron and light microscopy. The livers of 2 mutants were first observed to be grossly discolored owing to pigment accumulation at 7 and 11 weeks of age, respectively. The brownish-black pigment was primarily found in the pericanalicular dense bodies of centrilobular hepatocytes.

Original languageEnglish (US)
Pages (from-to)1072-1076
Number of pages5
JournalThe American Journal of Digestive Diseases
Issue number12
StatePublished - Dec 1 1968
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Gastroenterology


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