Dubin-Johnson syndrome in immature sheep

C. E. Cornelius, Bennie Osburn, R. R. Gronwall, G. H. Cardinet

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Hyperbilirubinemia and a delayed plasma clearance of sulfobromophthalein was observed in neonatal mutant lambs possessing a syndrome similar to Dubin-Johnson syndrome in man. Characteristic discoloration of the liver due to hepatocellular pigmentation was not discernible at birth when examined by electron and light microscopy. The livers of 2 mutants were first observed to be grossly discolored owing to pigment accumulation at 7 and 11 weeks of age, respectively. The brownish-black pigment was primarily found in the pericanalicular dense bodies of centrilobular hepatocytes.

Original languageEnglish (US)
Pages (from-to)1072-1076
Number of pages5
JournalThe American Journal of Digestive Diseases
Volume13
Issue number12
DOIs
StatePublished - Dec 1 1968
Externally publishedYes

Fingerprint

Chronic Idiopathic Jaundice
Sheep
Sulfobromophthalein
Hyperbilirubinemia
Liver
Pigmentation
Hepatocytes
Electron Microscopy
Parturition
Light

ASJC Scopus subject areas

  • Medicine(all)
  • Gastroenterology

Cite this

Cornelius, C. E., Osburn, B., Gronwall, R. R., & Cardinet, G. H. (1968). Dubin-Johnson syndrome in immature sheep. The American Journal of Digestive Diseases, 13(12), 1072-1076. https://doi.org/10.1007/BF02233553

Dubin-Johnson syndrome in immature sheep. / Cornelius, C. E.; Osburn, Bennie; Gronwall, R. R.; Cardinet, G. H.

In: The American Journal of Digestive Diseases, Vol. 13, No. 12, 01.12.1968, p. 1072-1076.

Research output: Contribution to journalArticle

Cornelius, CE, Osburn, B, Gronwall, RR & Cardinet, GH 1968, 'Dubin-Johnson syndrome in immature sheep', The American Journal of Digestive Diseases, vol. 13, no. 12, pp. 1072-1076. https://doi.org/10.1007/BF02233553
Cornelius CE, Osburn B, Gronwall RR, Cardinet GH. Dubin-Johnson syndrome in immature sheep. The American Journal of Digestive Diseases. 1968 Dec 1;13(12):1072-1076. https://doi.org/10.1007/BF02233553
Cornelius, C. E. ; Osburn, Bennie ; Gronwall, R. R. ; Cardinet, G. H. / Dubin-Johnson syndrome in immature sheep. In: The American Journal of Digestive Diseases. 1968 ; Vol. 13, No. 12. pp. 1072-1076.
@article{8d5fa87f56024d69ad8b26014befbd97,
title = "Dubin-Johnson syndrome in immature sheep",
abstract = "Hyperbilirubinemia and a delayed plasma clearance of sulfobromophthalein was observed in neonatal mutant lambs possessing a syndrome similar to Dubin-Johnson syndrome in man. Characteristic discoloration of the liver due to hepatocellular pigmentation was not discernible at birth when examined by electron and light microscopy. The livers of 2 mutants were first observed to be grossly discolored owing to pigment accumulation at 7 and 11 weeks of age, respectively. The brownish-black pigment was primarily found in the pericanalicular dense bodies of centrilobular hepatocytes.",
author = "Cornelius, {C. E.} and Bennie Osburn and Gronwall, {R. R.} and Cardinet, {G. H.}",
year = "1968",
month = "12",
day = "1",
doi = "10.1007/BF02233553",
language = "English (US)",
volume = "13",
pages = "1072--1076",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "12",

}

TY - JOUR

T1 - Dubin-Johnson syndrome in immature sheep

AU - Cornelius, C. E.

AU - Osburn, Bennie

AU - Gronwall, R. R.

AU - Cardinet, G. H.

PY - 1968/12/1

Y1 - 1968/12/1

N2 - Hyperbilirubinemia and a delayed plasma clearance of sulfobromophthalein was observed in neonatal mutant lambs possessing a syndrome similar to Dubin-Johnson syndrome in man. Characteristic discoloration of the liver due to hepatocellular pigmentation was not discernible at birth when examined by electron and light microscopy. The livers of 2 mutants were first observed to be grossly discolored owing to pigment accumulation at 7 and 11 weeks of age, respectively. The brownish-black pigment was primarily found in the pericanalicular dense bodies of centrilobular hepatocytes.

AB - Hyperbilirubinemia and a delayed plasma clearance of sulfobromophthalein was observed in neonatal mutant lambs possessing a syndrome similar to Dubin-Johnson syndrome in man. Characteristic discoloration of the liver due to hepatocellular pigmentation was not discernible at birth when examined by electron and light microscopy. The livers of 2 mutants were first observed to be grossly discolored owing to pigment accumulation at 7 and 11 weeks of age, respectively. The brownish-black pigment was primarily found in the pericanalicular dense bodies of centrilobular hepatocytes.

UR - http://www.scopus.com/inward/record.url?scp=0014365209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014365209&partnerID=8YFLogxK

U2 - 10.1007/BF02233553

DO - 10.1007/BF02233553

M3 - Article

C2 - 5749221

AN - SCOPUS:0014365209

VL - 13

SP - 1072

EP - 1076

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 12

ER -