Dubin-Johnson-like syndrome in golden lion tamarins (Leontopithecus rosalia rosalia).

F. Y. Schulman, R. J. Montali, M. Bush, S. B. Citino, Lisa A Tell, J. D. Ballou, T. L. Hutson, M. St Pierre, J. F. Dufour, Z. Gatmaitan

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Abstract

On routine blood screens, persistent conjugated hyperbilirubinemia was discovered in two groups of closely related adult female golden lion tamarins (Leontopithecus rosalia rosalia, n = 8). Bromosulfophthalein (BSP) retention tests were performed on four hyperbilirubinemic and three control tamarins. BSP excretion was delayed in hyperbilirubinemic tamarins as compared with controls. Grossly, liver of affected tamarins was dark brown to black, with a prominent reticulated pattern. Histologic examination revealed abundant intrahepatic pigment, primarily in a centrilobular and midzonal distribution. Most of the pigment did not react with Perls' Prussian blue method for iron, Hall's method for bilirubin, or the Armed Forces Institute of Pathology acid-fast method for lipofuscin but was positive with Fontana and lipofuscin-ferric ferricyanide reduction techniques. Liver from control golden lion tamarins had intrahepatocellular Perls' iron-positive pigment diffusely throughout the lobule with a small amount of Fontana method-positive pigment. Ultrastructurally, hepatocytes from a hyperbilirubinemic tamarin contained pleomorphic electron-dense structures within lysosomes. Transport studies demonstrated secretion of fluorescein isothiocyanate-labeled glycocholic acid, a fluorescent bile acid analog, into bile canaliculi and no secretion of carboxydichlorofluorescein diacetate, a non-bile acid organic anion, by liver from a hyperbilirubinemic tamarin. In contrast, control liver secreted carboxydichlorofluorescein diacetate readily into bile canaliculi. The clinicopathologic presentation of this syndrome in golden lion tamarins is similar to that described for Dubin-Johnson syndrome of human beings.

Original languageEnglish (US)
Pages (from-to)491-498
Number of pages8
JournalVeterinary Pathology
Volume30
Issue number6
StatePublished - Nov 1993
Externally publishedYes

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Leontopithecus
Chronic Idiopathic Jaundice
Rosalia
Leontopithecus rosalia
Callitrichidae
pigments
liver
Bile Canaliculi
bile
Sulfobromophthalein
Lipofuscin
glycocholic acid
Liver
secretion
iron
hyperbilirubinemia
ferricyanides
methodology
Iron
isothiocyanates

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Schulman, F. Y., Montali, R. J., Bush, M., Citino, S. B., Tell, L. A., Ballou, J. D., ... Gatmaitan, Z. (1993). Dubin-Johnson-like syndrome in golden lion tamarins (Leontopithecus rosalia rosalia). Veterinary Pathology, 30(6), 491-498.

Dubin-Johnson-like syndrome in golden lion tamarins (Leontopithecus rosalia rosalia). / Schulman, F. Y.; Montali, R. J.; Bush, M.; Citino, S. B.; Tell, Lisa A; Ballou, J. D.; Hutson, T. L.; St Pierre, M.; Dufour, J. F.; Gatmaitan, Z.

In: Veterinary Pathology, Vol. 30, No. 6, 11.1993, p. 491-498.

Research output: Contribution to journalArticle

Schulman, FY, Montali, RJ, Bush, M, Citino, SB, Tell, LA, Ballou, JD, Hutson, TL, St Pierre, M, Dufour, JF & Gatmaitan, Z 1993, 'Dubin-Johnson-like syndrome in golden lion tamarins (Leontopithecus rosalia rosalia).', Veterinary Pathology, vol. 30, no. 6, pp. 491-498.
Schulman FY, Montali RJ, Bush M, Citino SB, Tell LA, Ballou JD et al. Dubin-Johnson-like syndrome in golden lion tamarins (Leontopithecus rosalia rosalia). Veterinary Pathology. 1993 Nov;30(6):491-498.
Schulman, F. Y. ; Montali, R. J. ; Bush, M. ; Citino, S. B. ; Tell, Lisa A ; Ballou, J. D. ; Hutson, T. L. ; St Pierre, M. ; Dufour, J. F. ; Gatmaitan, Z. / Dubin-Johnson-like syndrome in golden lion tamarins (Leontopithecus rosalia rosalia). In: Veterinary Pathology. 1993 ; Vol. 30, No. 6. pp. 491-498.
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abstract = "On routine blood screens, persistent conjugated hyperbilirubinemia was discovered in two groups of closely related adult female golden lion tamarins (Leontopithecus rosalia rosalia, n = 8). Bromosulfophthalein (BSP) retention tests were performed on four hyperbilirubinemic and three control tamarins. BSP excretion was delayed in hyperbilirubinemic tamarins as compared with controls. Grossly, liver of affected tamarins was dark brown to black, with a prominent reticulated pattern. Histologic examination revealed abundant intrahepatic pigment, primarily in a centrilobular and midzonal distribution. Most of the pigment did not react with Perls' Prussian blue method for iron, Hall's method for bilirubin, or the Armed Forces Institute of Pathology acid-fast method for lipofuscin but was positive with Fontana and lipofuscin-ferric ferricyanide reduction techniques. Liver from control golden lion tamarins had intrahepatocellular Perls' iron-positive pigment diffusely throughout the lobule with a small amount of Fontana method-positive pigment. Ultrastructurally, hepatocytes from a hyperbilirubinemic tamarin contained pleomorphic electron-dense structures within lysosomes. Transport studies demonstrated secretion of fluorescein isothiocyanate-labeled glycocholic acid, a fluorescent bile acid analog, into bile canaliculi and no secretion of carboxydichlorofluorescein diacetate, a non-bile acid organic anion, by liver from a hyperbilirubinemic tamarin. In contrast, control liver secreted carboxydichlorofluorescein diacetate readily into bile canaliculi. The clinicopathologic presentation of this syndrome in golden lion tamarins is similar to that described for Dubin-Johnson syndrome of human beings.",
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AU - Montali, R. J.

AU - Bush, M.

AU - Citino, S. B.

AU - Tell, Lisa A

AU - Ballou, J. D.

AU - Hutson, T. L.

AU - St Pierre, M.

AU - Dufour, J. F.

AU - Gatmaitan, Z.

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