Dual roles of oxidative stress in the lungs

Tzipora Goldkorn, Elaine M. Khan

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

The redox state of the cell plays an important part in processes such as tumor progression, aging, atherosclerosis, chronic inflammatory processes, lung injuries and neurodegenerative diseases. Increased levels of intracellular reactive oxygen species (ROS) above normal basal levels are defined as cellular oxidative stress. ROS include superoxide anions (O2 .-), hydroxyl radicals and hydrogen peroxide (H2O2), which can be further changed into highly reactive hydroxyl radicals via iron-catalyzed Fenton reactions under pathological conditions. O2 .- can also rapidly react with nitric oxide (NO) to generate a stable free radical, peroxynitrite (OONO.-), which is a strong cytotoxic oxidant. Typically, oxidative stress is generated by increased production of ROS and/ or by damage to the antioxidant defense system during cellular processes (Sies, 1997; Hoidal, 2001; Sen and Packer, 1996). Oxidative stress can also be introduced by exogenous sources such as air pollutants and cigarette smoke. Since the lungs contain the largest surface area of epithelial and endothelial cells of any organ, they are at high risk for injury from inhalation of high concentrations of ROS.

Original languageEnglish (US)
Title of host publicationOxidants in Biology: A Question of Balance
PublisherSpringer Netherlands
Pages231-250
Number of pages20
ISBN (Print)9781402083983
DOIs
StatePublished - 2008

Fingerprint

reactive oxygen species
Reactive Oxygen Species
Oxidative Stress
oxidative stress
lungs
Lung
hydroxyl radicals
Hydroxyl Radical
exogenous sources
Organs at Risk
Air Pollutants
Peroxynitrous Acid
cigarettes
neurodegenerative diseases
Lung Injury
smoke
atherosclerosis
Oxidants
oxidants
Smoke

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Goldkorn, T., & Khan, E. M. (2008). Dual roles of oxidative stress in the lungs. In Oxidants in Biology: A Question of Balance (pp. 231-250). Springer Netherlands. https://doi.org/10.1007/978-1-4020-8399-0_11

Dual roles of oxidative stress in the lungs. / Goldkorn, Tzipora; Khan, Elaine M.

Oxidants in Biology: A Question of Balance. Springer Netherlands, 2008. p. 231-250.

Research output: Chapter in Book/Report/Conference proceedingChapter

Goldkorn, T & Khan, EM 2008, Dual roles of oxidative stress in the lungs. in Oxidants in Biology: A Question of Balance. Springer Netherlands, pp. 231-250. https://doi.org/10.1007/978-1-4020-8399-0_11
Goldkorn T, Khan EM. Dual roles of oxidative stress in the lungs. In Oxidants in Biology: A Question of Balance. Springer Netherlands. 2008. p. 231-250 https://doi.org/10.1007/978-1-4020-8399-0_11
Goldkorn, Tzipora ; Khan, Elaine M. / Dual roles of oxidative stress in the lungs. Oxidants in Biology: A Question of Balance. Springer Netherlands, 2008. pp. 231-250
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