Dual-modality fluorescence lifetime and intravascular ultrasound for label-free intravascular coronary imaging

Jennifer E. Phipps, Julien Bec, Laura Marcu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Atherosclerosis in the coronary arteries accounts for nearly 50% of cardiovascular disease-related deaths. To characterize an atherosclerotic disease, imaging modalities that measure both the biochemical and structural properties of the lesions in the coronary arteries are necessary. To accomplish this, time-resolved fluorescence spectroscopy (TRFS) can be used to determine biochemical composition while adding diagnostic value to intravascular ultrasound (IVUS), which identifies structural features of the arterial wall. Healthy and diseased human arteries have distinct autofluorescent properties that allow specific biochemical features of atherosclerosis to be characterized with ultraviolet light excitation.

Original languageEnglish (US)
Title of host publicationMultimodality Imaging
Subtitle of host publicationFor Intravascular Application
PublisherSpringer Singapore
Pages153-171
Number of pages19
ISBN (Electronic)9789811063077
ISBN (Print)9789811063060
DOIs
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • Medicine(all)
  • Health Professions(all)
  • Physics and Astronomy(all)
  • Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Phipps, J. E., Bec, J., & Marcu, L. (2019). Dual-modality fluorescence lifetime and intravascular ultrasound for label-free intravascular coronary imaging. In Multimodality Imaging: For Intravascular Application (pp. 153-171). Springer Singapore. https://doi.org/10.1007/978-981-10-6307-7_6