Abstract
To determine whether gadodiamide injection can provide sufficient enhancement on both T1- and T2-weighted spin-echo magnetic resonance (MR) images of the heart and skeletal muscles, anesthetized rats were divided into five groups. Groups 1-3 received 0.1 (n = 9), 0.3 (n = 8), or 0.5 (n = 8) mmol/kg gadodiamide injection, respectively, and T1-weighted images were obtained. Groups 4 and 5 received 0.3 or 0.5 mmol/kg gadodiamide injection; respectively, and T2-weighted images were obtained. Gadolinium concentration was measured in myocardium by means of inductively coupled plasma-atomic emission spectroscopy. On T1-weighted images, the 0.1 and 0.3 mmol/kg doses produced a dose-dependent increase in myocardial signal intensity proportional to gadolinium concentration. A dose of 0.5 mmol/kg, which correlated with higher gadolinium concentration and did not further increase myocardial signal intensity, prolonged the imaging window. On T2-weighted images, the 0.3 mmol/kg dose caused a transient decrease in myocardial signal intensity; the 0.5 mmol/kg dose produced greater and persistent loss of signal intensity. In conclusion, the changes in signal intensity induced by gadodiamide injection depend on the dose, pulse sequence, and type of tissue.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-182 |
| Number of pages | 8 |
| Journal | Radiology |
| Volume | 186 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
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Keywords
- Gadolinium
- Magnetic resonance (MR), contrast enhancement
- Magnetic resonance (MR), pulse sequences
- Muscles, MR
- Myocardium, MR
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Dual mechanisms for change in myocardial signal intensity by means of a single MR contrast medium : Dependence on concentration and pulse sequence. / Saeed, M.; Wendland, M. F.; Masui, T.; Yu, K. K.; Li, Jian-Jian; Derugin, N.; Higgins, C. B.
In: Radiology, Vol. 186, No. 1, 01.01.1993, p. 175-182.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dual mechanisms for change in myocardial signal intensity by means of a single MR contrast medium
T2 - Dependence on concentration and pulse sequence
AU - Saeed, M.
AU - Wendland, M. F.
AU - Masui, T.
AU - Yu, K. K.
AU - Li, Jian-Jian
AU - Derugin, N.
AU - Higgins, C. B.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - To determine whether gadodiamide injection can provide sufficient enhancement on both T1- and T2-weighted spin-echo magnetic resonance (MR) images of the heart and skeletal muscles, anesthetized rats were divided into five groups. Groups 1-3 received 0.1 (n = 9), 0.3 (n = 8), or 0.5 (n = 8) mmol/kg gadodiamide injection, respectively, and T1-weighted images were obtained. Groups 4 and 5 received 0.3 or 0.5 mmol/kg gadodiamide injection; respectively, and T2-weighted images were obtained. Gadolinium concentration was measured in myocardium by means of inductively coupled plasma-atomic emission spectroscopy. On T1-weighted images, the 0.1 and 0.3 mmol/kg doses produced a dose-dependent increase in myocardial signal intensity proportional to gadolinium concentration. A dose of 0.5 mmol/kg, which correlated with higher gadolinium concentration and did not further increase myocardial signal intensity, prolonged the imaging window. On T2-weighted images, the 0.3 mmol/kg dose caused a transient decrease in myocardial signal intensity; the 0.5 mmol/kg dose produced greater and persistent loss of signal intensity. In conclusion, the changes in signal intensity induced by gadodiamide injection depend on the dose, pulse sequence, and type of tissue.
AB - To determine whether gadodiamide injection can provide sufficient enhancement on both T1- and T2-weighted spin-echo magnetic resonance (MR) images of the heart and skeletal muscles, anesthetized rats were divided into five groups. Groups 1-3 received 0.1 (n = 9), 0.3 (n = 8), or 0.5 (n = 8) mmol/kg gadodiamide injection, respectively, and T1-weighted images were obtained. Groups 4 and 5 received 0.3 or 0.5 mmol/kg gadodiamide injection; respectively, and T2-weighted images were obtained. Gadolinium concentration was measured in myocardium by means of inductively coupled plasma-atomic emission spectroscopy. On T1-weighted images, the 0.1 and 0.3 mmol/kg doses produced a dose-dependent increase in myocardial signal intensity proportional to gadolinium concentration. A dose of 0.5 mmol/kg, which correlated with higher gadolinium concentration and did not further increase myocardial signal intensity, prolonged the imaging window. On T2-weighted images, the 0.3 mmol/kg dose caused a transient decrease in myocardial signal intensity; the 0.5 mmol/kg dose produced greater and persistent loss of signal intensity. In conclusion, the changes in signal intensity induced by gadodiamide injection depend on the dose, pulse sequence, and type of tissue.
KW - Gadolinium
KW - Magnetic resonance (MR), contrast enhancement
KW - Magnetic resonance (MR), pulse sequences
KW - Muscles, MR
KW - Myocardium, MR
UR - http://www.scopus.com/inward/record.url?scp=0027492215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027492215&partnerID=8YFLogxK
U2 - 10.1148/radiology.186.1.8416560
DO - 10.1148/radiology.186.1.8416560
M3 - Article
C2 - 8416560
AN - SCOPUS:0027492215
VL - 186
SP - 175
EP - 182
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 1
ER -