Dual mechanism platypnea-orthodeoxia syndrome from severe right coronary artery stenosis and a patent foramen ovale

Keong Yeo Khung, Jason H Rogers

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Platypnea-orthodeoxia is a rare clinical syndrome characterized by hypoxemia induced during upright posture. Multiple mechanisms have been proposed to explain this clinical entity, usually involving posture-provoked intracardiac or transpulmonary shunting. In many cases, however, a single etiology may not be evident, and multiple factors are likely contributory. We herein describe an unusual and novel case of platypnea-orthodeoxia caused by the physiologic interaction between a severe proximal right coronary artery stenosis and a large patent foramen ovale. Percutaneous stenting of the right coronary artery and transcatheter closure of the patent foramen ovale during the same setting resulted in complete resolution of the patient's symptoms.

Original languageEnglish (US)
Pages (from-to)440-444
Number of pages5
JournalCatheterization and Cardiovascular Interventions
Volume70
Issue number3
DOIs
StatePublished - Sep 1 2007

Fingerprint

Patent Foramen Ovale
Coronary Stenosis
Posture
Coronary Vessels
Hypoxia

Keywords

  • Atrial septal defects
  • Percutaneous coronary intervention
  • Transcatheter intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "Platypnea-orthodeoxia is a rare clinical syndrome characterized by hypoxemia induced during upright posture. Multiple mechanisms have been proposed to explain this clinical entity, usually involving posture-provoked intracardiac or transpulmonary shunting. In many cases, however, a single etiology may not be evident, and multiple factors are likely contributory. We herein describe an unusual and novel case of platypnea-orthodeoxia caused by the physiologic interaction between a severe proximal right coronary artery stenosis and a large patent foramen ovale. Percutaneous stenting of the right coronary artery and transcatheter closure of the patent foramen ovale during the same setting resulted in complete resolution of the patient's symptoms.",
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AB - Platypnea-orthodeoxia is a rare clinical syndrome characterized by hypoxemia induced during upright posture. Multiple mechanisms have been proposed to explain this clinical entity, usually involving posture-provoked intracardiac or transpulmonary shunting. In many cases, however, a single etiology may not be evident, and multiple factors are likely contributory. We herein describe an unusual and novel case of platypnea-orthodeoxia caused by the physiologic interaction between a severe proximal right coronary artery stenosis and a large patent foramen ovale. Percutaneous stenting of the right coronary artery and transcatheter closure of the patent foramen ovale during the same setting resulted in complete resolution of the patient's symptoms.

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