Dual-Input Kinetic Modeling in Dynamic PET: Clinical Evaluation of the Impact of Time-of-Flight Imaging

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dynamic 18F-FDG PET has the promise of noninvasively measuring liver inflammation by means of tracer kinetic modeling. A unique feature of dynamic liver PET is that dual-input kinetic modeling is required for considering the dual-blood supply to the liver. While time-of-flight (TOF) reconstruction is expected to improve kinetic quantification over non-TOF imaging, it is unclear how the improvement by TOF interacts with tracer kinetic modeling and if the benefit of TOF can be transferred into improving the correlation of PET biomarkers with histopathology. In this paper, we investigate the impact of TOF imaging on conventional single-input kinetic modeling and new dual-input kinetic modeling using patient data of liver imaging and histopathological data. The results have shown that TOF imaging has a minimal effect on single-input kinetic modeling but is more impactful on the dual-input kinetic modeling approach. Combined use of the dual-input model and TOF is crucial for improving the correlation of the PET biomaker with liver inflammation.

Original languageEnglish (US)
Title of host publication2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538684948
DOIs
StatePublished - Nov 2018
Event2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Sydney, Australia
Duration: Nov 10 2018Nov 17 2018

Publication series

Name2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings

Conference

Conference2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018
CountryAustralia
CitySydney
Period11/10/1811/17/18

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Nuclear and High Energy Physics

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