Dual-energy multi-detector row CT with virtual monochromatic imaging for improving patient-to-patient uniformity of aortic enhancement during CT angiography

An in vitro and in vivo study

Daniele Marin, Ghaneh Fananapazir, Achille Mileto, Kingshuk Roy Choudhury, Joshua M. Wilson, Rendon C. Nelson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: To determine whether virtual monochromatic imaging from a dual-energy acquisition can improve patient-to-patient uniformity of aortic enhancement during multi-detector row computed tomographic (CT) angiography. Materials and Methods: This retrospective single-center HIPAA-compliant study was approved by the institutional review board, with a waiver of informed consent. A proprietary tapered hollow phantom that contained a bone-mimicking insert and a hollow tube insert that mimicked the aorta was used. The aortic insert was filled with different iodine dilutions to mimic various degrees of enhancement. The phantom was imaged with both dual-energy and single-energy multi-detector row CT at four energy levels (80, 100, 120, and 140 kVp). Dual-energy multi-detector row CT was also performed in 62 patients (38 men; mean age, 60 years ± 12.7 [standard deviation]). For both the phantom and the patients, virtual monochromatic images were reconstructed from 40 to 140 keV, at 20-keV increments. The relationship between aortic attenuation and effective diameter was assessed by using a statistical model. Results: For all polychromatic data sets, the mean aortic attenuation decreased proportionally to the effective diameter of the phantom (slope, ≥3.0 HU/cm). For virtual monochromatic data sets ranging from 80 to 140 keV, the regression slopes of aortic attenuation as a function of the phantom's effective diameter were negligible (slope, <1.0 HU/cm) for all iodine-to-water dilutions. In patients, the slope of the regression lines was also negligible (-0.69 < slope < 0.16) for virtual monochromatic data sets ranging from 100 to 140 keV. Conclusion: Within an energy range of 100-140 keV, virtual monochromatic images improve patient-to-patient uniformity of aortic enhancement compared with conventional polychromatic acquisitions.

Original languageEnglish (US)
Pages (from-to)895-902
Number of pages8
JournalRadiology
Volume272
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

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Angiography
Iodine
Health Insurance Portability and Accountability Act
Research Ethics Committees
Statistical Models
In Vitro Techniques
Informed Consent
Aorta
Bone and Bones
Water
Datasets

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Dual-energy multi-detector row CT with virtual monochromatic imaging for improving patient-to-patient uniformity of aortic enhancement during CT angiography : An in vitro and in vivo study. / Marin, Daniele; Fananapazir, Ghaneh; Mileto, Achille; Choudhury, Kingshuk Roy; Wilson, Joshua M.; Nelson, Rendon C.

In: Radiology, Vol. 272, No. 3, 2014, p. 895-902.

Research output: Contribution to journalArticle

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abstract = "Purpose: To determine whether virtual monochromatic imaging from a dual-energy acquisition can improve patient-to-patient uniformity of aortic enhancement during multi-detector row computed tomographic (CT) angiography. Materials and Methods: This retrospective single-center HIPAA-compliant study was approved by the institutional review board, with a waiver of informed consent. A proprietary tapered hollow phantom that contained a bone-mimicking insert and a hollow tube insert that mimicked the aorta was used. The aortic insert was filled with different iodine dilutions to mimic various degrees of enhancement. The phantom was imaged with both dual-energy and single-energy multi-detector row CT at four energy levels (80, 100, 120, and 140 kVp). Dual-energy multi-detector row CT was also performed in 62 patients (38 men; mean age, 60 years ± 12.7 [standard deviation]). For both the phantom and the patients, virtual monochromatic images were reconstructed from 40 to 140 keV, at 20-keV increments. The relationship between aortic attenuation and effective diameter was assessed by using a statistical model. Results: For all polychromatic data sets, the mean aortic attenuation decreased proportionally to the effective diameter of the phantom (slope, ≥3.0 HU/cm). For virtual monochromatic data sets ranging from 80 to 140 keV, the regression slopes of aortic attenuation as a function of the phantom's effective diameter were negligible (slope, <1.0 HU/cm) for all iodine-to-water dilutions. In patients, the slope of the regression lines was also negligible (-0.69 < slope < 0.16) for virtual monochromatic data sets ranging from 100 to 140 keV. Conclusion: Within an energy range of 100-140 keV, virtual monochromatic images improve patient-to-patient uniformity of aortic enhancement compared with conventional polychromatic acquisitions.",
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AU - Marin, Daniele

AU - Fananapazir, Ghaneh

AU - Mileto, Achille

AU - Choudhury, Kingshuk Roy

AU - Wilson, Joshua M.

AU - Nelson, Rendon C.

PY - 2014

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N2 - Purpose: To determine whether virtual monochromatic imaging from a dual-energy acquisition can improve patient-to-patient uniformity of aortic enhancement during multi-detector row computed tomographic (CT) angiography. Materials and Methods: This retrospective single-center HIPAA-compliant study was approved by the institutional review board, with a waiver of informed consent. A proprietary tapered hollow phantom that contained a bone-mimicking insert and a hollow tube insert that mimicked the aorta was used. The aortic insert was filled with different iodine dilutions to mimic various degrees of enhancement. The phantom was imaged with both dual-energy and single-energy multi-detector row CT at four energy levels (80, 100, 120, and 140 kVp). Dual-energy multi-detector row CT was also performed in 62 patients (38 men; mean age, 60 years ± 12.7 [standard deviation]). For both the phantom and the patients, virtual monochromatic images were reconstructed from 40 to 140 keV, at 20-keV increments. The relationship between aortic attenuation and effective diameter was assessed by using a statistical model. Results: For all polychromatic data sets, the mean aortic attenuation decreased proportionally to the effective diameter of the phantom (slope, ≥3.0 HU/cm). For virtual monochromatic data sets ranging from 80 to 140 keV, the regression slopes of aortic attenuation as a function of the phantom's effective diameter were negligible (slope, <1.0 HU/cm) for all iodine-to-water dilutions. In patients, the slope of the regression lines was also negligible (-0.69 < slope < 0.16) for virtual monochromatic data sets ranging from 100 to 140 keV. Conclusion: Within an energy range of 100-140 keV, virtual monochromatic images improve patient-to-patient uniformity of aortic enhancement compared with conventional polychromatic acquisitions.

AB - Purpose: To determine whether virtual monochromatic imaging from a dual-energy acquisition can improve patient-to-patient uniformity of aortic enhancement during multi-detector row computed tomographic (CT) angiography. Materials and Methods: This retrospective single-center HIPAA-compliant study was approved by the institutional review board, with a waiver of informed consent. A proprietary tapered hollow phantom that contained a bone-mimicking insert and a hollow tube insert that mimicked the aorta was used. The aortic insert was filled with different iodine dilutions to mimic various degrees of enhancement. The phantom was imaged with both dual-energy and single-energy multi-detector row CT at four energy levels (80, 100, 120, and 140 kVp). Dual-energy multi-detector row CT was also performed in 62 patients (38 men; mean age, 60 years ± 12.7 [standard deviation]). For both the phantom and the patients, virtual monochromatic images were reconstructed from 40 to 140 keV, at 20-keV increments. The relationship between aortic attenuation and effective diameter was assessed by using a statistical model. Results: For all polychromatic data sets, the mean aortic attenuation decreased proportionally to the effective diameter of the phantom (slope, ≥3.0 HU/cm). For virtual monochromatic data sets ranging from 80 to 140 keV, the regression slopes of aortic attenuation as a function of the phantom's effective diameter were negligible (slope, <1.0 HU/cm) for all iodine-to-water dilutions. In patients, the slope of the regression lines was also negligible (-0.69 < slope < 0.16) for virtual monochromatic data sets ranging from 100 to 140 keV. Conclusion: Within an energy range of 100-140 keV, virtual monochromatic images improve patient-to-patient uniformity of aortic enhancement compared with conventional polychromatic acquisitions.

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