Dual effects of substance P on the excitability of single cutaneous primary afferent C- and A-fibers in the cat spinal cord

M. Randić, Earl Carstens, M. Zimmermann, D. Klumpp

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Excitability of testing of single sural afferent C- and A-fibers was used to study possible presynaptic actions of substance P (SP) applied locally or systemically at the in traspinal sites of minimal threshold for their antidromic activation in anesthetized or spinalized cats. SP, applied by iontophoresis, pressure microinjection or systemically, produced dose-related reversible decreases or increases in threshold for antidromic activation of both C- and A-fibers. It was concluded that, in addition to previously shown postsynaptic actions, SP modifies excitability of intraspinal cutaneous C- and A-fibers.

Original languageEnglish (US)
Pages (from-to)389-393
Number of pages5
JournalBrain Research
Volume233
Issue number2
DOIs
StatePublished - Feb 11 1982
Externally publishedYes

Keywords

  • A-fibers
  • C-fibers
  • cat spinal cord
  • primary afferents
  • substance P

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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