Drugs for the Prevention and Treatment of Bronchopulmonary Dysplasia

Erica W. Mandell, Panagiotis Kratimenos, Steven H. Abman, Robin H Steinhorn

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Rates of bronchopulmonary dysplasia (BPD) are increasing. After preterm birth, there are important developmental periods in which neonates are more vulnerable to stressful events. These periods are opportunities for pharmacologic interventions. Many drugs remain inadequately tested and no new drugs have been approved in more than 25 years for BPD prevention or therapy. More progress is needed in defining appropriate end points based on the pathophysiology of BPD and postdischarge chronic pulmonary insufficiency of prematurity and to develop effective new drugs. In addition, much work is needed to better define perinatal factors, early postnatal findings, and physiologic phenotypes or endotypes.

Original languageEnglish (US)
JournalClinics in Perinatology
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Bronchopulmonary dysplasia
  • Chronic pulmonary insufficiency of prematurity
  • Lungs
  • Pharmacology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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