Abstract
The potential for compounds acting at the strychnine-insensitive glycine receptor to injure neurons was examined using induction of a 70 kDa heat shock protein (HSP-70) as a marker. HSP-70 was consistently detected in retrosplenial and cingulate cortices after MK-801 but not glycine drug treatment. Elsewhere in the cortex, mild diffuse HSP-70 immunoreactivity was detected following 7-chlorokynurenic acid. Following HA-966, intense hippocampal HSP-70 immunoreactivity was observed. These findings indicate that even after very high doses, drugs acting at the strychnine-insensitive glycine receptor are less likely to injure cingulate cortical neurons than other classes of NMDA antagonists.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 147-150 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 168 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Feb 28 1994 |
| Externally published | Yes |
Keywords
- 7-Chlorokynurenic acid
- ACPC
- d-Cycloserine
- Glycine
- HA-966
- NMDA
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Berger, P., Farrel, K., Sharp, F. R., & Skolnick, P. (1994). Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex. Neuroscience Letters, 168(1-2), 147-150. https://doi.org/10.1016/0304-3940(94)90437-5