Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex

Paul Berger; Kevin Farrel; Frank R Sharp; Phil Skolnick

doi:10.1016/0304-3940(94)90437-5

Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex

Paul Berger, Kevin Farrel, Frank R Sharp, Phil Skolnick

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The potential for compounds acting at the strychnine-insensitive glycine receptor to injure neurons was examined using induction of a 70 kDa heat shock protein (HSP-70) as a marker. HSP-70 was consistently detected in retrosplenial and cingulate cortices after MK-801 but not glycine drug treatment. Elsewhere in the cortex, mild diffuse HSP-70 immunoreactivity was detected following 7-chlorokynurenic acid. Following HA-966, intense hippocampal HSP-70 immunoreactivity was observed. These findings indicate that even after very high doses, drugs acting at the strychnine-insensitive glycine receptor are less likely to injure cingulate cortical neurons than other classes of NMDA antagonists.

Original language	English (US)
Pages (from-to)	147-150
Number of pages	4
Journal	Neuroscience Letters
Volume	168
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)90437-5
State	Published - Feb 28 1994
Externally published	Yes

Keywords

7-Chlorokynurenic acid
ACPC
d-Cycloserine
Glycine
HA-966
NMDA

ASJC Scopus subject areas

Neuroscience(all)

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title = "Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex",

abstract = "The potential for compounds acting at the strychnine-insensitive glycine receptor to injure neurons was examined using induction of a 70 kDa heat shock protein (HSP-70) as a marker. HSP-70 was consistently detected in retrosplenial and cingulate cortices after MK-801 but not glycine drug treatment. Elsewhere in the cortex, mild diffuse HSP-70 immunoreactivity was detected following 7-chlorokynurenic acid. Following HA-966, intense hippocampal HSP-70 immunoreactivity was observed. These findings indicate that even after very high doses, drugs acting at the strychnine-insensitive glycine receptor are less likely to injure cingulate cortical neurons than other classes of NMDA antagonists.",

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AU - Sharp, Frank R

AU - Skolnick, Phil

PY - 1994/2/28

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AB - The potential for compounds acting at the strychnine-insensitive glycine receptor to injure neurons was examined using induction of a 70 kDa heat shock protein (HSP-70) as a marker. HSP-70 was consistently detected in retrosplenial and cingulate cortices after MK-801 but not glycine drug treatment. Elsewhere in the cortex, mild diffuse HSP-70 immunoreactivity was detected following 7-chlorokynurenic acid. Following HA-966, intense hippocampal HSP-70 immunoreactivity was observed. These findings indicate that even after very high doses, drugs acting at the strychnine-insensitive glycine receptor are less likely to injure cingulate cortical neurons than other classes of NMDA antagonists.

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KW - ACPC

KW - d-Cycloserine

KW - Glycine

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Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex

Abstract

Keywords

ASJC Scopus subject areas

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