Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex

Paul Berger, Kevin Farrel, Frank R Sharp, Phil Skolnick

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The potential for compounds acting at the strychnine-insensitive glycine receptor to injure neurons was examined using induction of a 70 kDa heat shock protein (HSP-70) as a marker. HSP-70 was consistently detected in retrosplenial and cingulate cortices after MK-801 but not glycine drug treatment. Elsewhere in the cortex, mild diffuse HSP-70 immunoreactivity was detected following 7-chlorokynurenic acid. Following HA-966, intense hippocampal HSP-70 immunoreactivity was observed. These findings indicate that even after very high doses, drugs acting at the strychnine-insensitive glycine receptor are less likely to injure cingulate cortical neurons than other classes of NMDA antagonists.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalNeuroscience Letters
Volume168
Issue number1-2
DOIs
StatePublished - Feb 28 1994
Externally publishedYes

Fingerprint

Gyrus Cinguli
Neurons
HSP70 Heat-Shock Proteins
Dizocilpine Maleate
N-Methylaspartate
Pharmaceutical Preparations
Glycine
Proteins
strychnine-insensitive glycine receptor
7-chlorokynurenic acid
1-hydroxy-3-amino-2-pyrrolidone

Keywords

  • 7-Chlorokynurenic acid
  • ACPC
  • d-Cycloserine
  • Glycine
  • HA-966
  • NMDA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex. / Berger, Paul; Farrel, Kevin; Sharp, Frank R; Skolnick, Phil.

In: Neuroscience Letters, Vol. 168, No. 1-2, 28.02.1994, p. 147-150.

Research output: Contribution to journalArticle

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