Drug-resistant tuberculosis in Shanghai, China, 2000-2006: Prevalence, trends and risk factors

X. Shen, K. DeRiemer, Z. An Yuan, M. Shen, Z. Xia, X. Gui, L. Wang, Qian Gao, Jian Mei

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Abstract

SETTING: During 2000-2006, a regional anti-tuberculosis drug resistance surveillance study was conducted in Shanghai, China. OBJECTIVE: To determine the prevalence, trends and risk factors for drug-resistant tuberculosis (TB) in Shanghai, China. DESIGN: A retrospective study of all pulmonary TB patients reported in Shanghai during 2000-2006 was conducted. RESULTS: Of 8419 pulmonary TB patients, 16.6% had resistance to any first-line anti-tuberculosis drug and 4.0% had multidrug resistance (MDR). The percentage of TB patients with resistance to any first-line antituberculosis drug and MDR significantly increased during 2000-2003 (P = 0.01 and P < 0.01, respectively). After improvements in the TB control programme in 2004, the increasing trend in drug resistance was contained. Age 30-59 years, being an urban migrant and residence in an urban area of Shanghai were independently associated with resistance to any first-line drug and MDR in new cases, while age 30-59 years and being an urban migrant were independently associated with resistance to any first-line drug and MDR in previously treated cases. CONCLUSIONS: Drug-resistant TB and MDR-TB pose a challenge for TB control in Shanghai. Improved case management, including DOTS and appropriate treatment regimens, should be sustained to prevent further transmission and development of drug-resistant TB in this setting.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume13
Issue number2
StatePublished - Feb 2009

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Multidrug-Resistant Tuberculosis
Multiple Drug Resistance
China
Drug Resistance
Tuberculosis
Pulmonary Tuberculosis
Case Management
Retrospective Studies
Pharmaceutical Preparations

Keywords

  • Drug resistance
  • Epidemiology
  • MDR-TB
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Shen, X., DeRiemer, K., Yuan, Z. A., Shen, M., Xia, Z., Gui, X., ... Mei, J. (2009). Drug-resistant tuberculosis in Shanghai, China, 2000-2006: Prevalence, trends and risk factors. International Journal of Tuberculosis and Lung Disease, 13(2), 253-259.

Drug-resistant tuberculosis in Shanghai, China, 2000-2006 : Prevalence, trends and risk factors. / Shen, X.; DeRiemer, K.; Yuan, Z. An; Shen, M.; Xia, Z.; Gui, X.; Wang, L.; Gao, Qian; Mei, Jian.

In: International Journal of Tuberculosis and Lung Disease, Vol. 13, No. 2, 02.2009, p. 253-259.

Research output: Contribution to journalArticle

Shen, X, DeRiemer, K, Yuan, ZA, Shen, M, Xia, Z, Gui, X, Wang, L, Gao, Q & Mei, J 2009, 'Drug-resistant tuberculosis in Shanghai, China, 2000-2006: Prevalence, trends and risk factors', International Journal of Tuberculosis and Lung Disease, vol. 13, no. 2, pp. 253-259.
Shen, X. ; DeRiemer, K. ; Yuan, Z. An ; Shen, M. ; Xia, Z. ; Gui, X. ; Wang, L. ; Gao, Qian ; Mei, Jian. / Drug-resistant tuberculosis in Shanghai, China, 2000-2006 : Prevalence, trends and risk factors. In: International Journal of Tuberculosis and Lung Disease. 2009 ; Vol. 13, No. 2. pp. 253-259.
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AU - Xia, Z.

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AU - Gao, Qian

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AB - SETTING: During 2000-2006, a regional anti-tuberculosis drug resistance surveillance study was conducted in Shanghai, China. OBJECTIVE: To determine the prevalence, trends and risk factors for drug-resistant tuberculosis (TB) in Shanghai, China. DESIGN: A retrospective study of all pulmonary TB patients reported in Shanghai during 2000-2006 was conducted. RESULTS: Of 8419 pulmonary TB patients, 16.6% had resistance to any first-line anti-tuberculosis drug and 4.0% had multidrug resistance (MDR). The percentage of TB patients with resistance to any first-line antituberculosis drug and MDR significantly increased during 2000-2003 (P = 0.01 and P < 0.01, respectively). After improvements in the TB control programme in 2004, the increasing trend in drug resistance was contained. Age 30-59 years, being an urban migrant and residence in an urban area of Shanghai were independently associated with resistance to any first-line drug and MDR in new cases, while age 30-59 years and being an urban migrant were independently associated with resistance to any first-line drug and MDR in previously treated cases. CONCLUSIONS: Drug-resistant TB and MDR-TB pose a challenge for TB control in Shanghai. Improved case management, including DOTS and appropriate treatment regimens, should be sustained to prevent further transmission and development of drug-resistant TB in this setting.

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