Drug induced acute erosive gastritis. Its prevention by antacid, metiamide and cimetidine

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

The usefulness of antiinflammatory and analgesic drugs such as aspirin, indomethacin, phenylbutazone etc. is often limited by gastrointestinal side effects, especially gastric bleeding. Newer antiinflammatory drugs such as naproxen, ketoprofen, ibuprofen and tolectin have been introduced. These agents were suggested to be less injurious to the gastric mucosa but massive gastric bleeding was seen after their use in the rat and in man. Other drugs such as colchicine, D-penicillamine, L-Dopa and capasaicin are also suspected of causing gastric injury. Some of these drugs, like bile salts, can disrupt the gastric mucosal barrier and thus allow back diffusion of H+. The presence of gastric acid probably is necessary for the occurrence of acute erosions. This study was designed to find out if various drugs given by esophageal intubation to rats would produce acute gastric erosions, which they did. The prevention of such erosions by the prior administration of antacids like mylanta II or metiamide and cimetidine (H2 receptor antagonists which inhibit gastric acid production) was confirmed.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Proctology Gastroenterology and Colon and Rectal Surgery
Pages23-28
Number of pages6
Volume28
Edition2
StatePublished - 1977
Externally publishedYes

Fingerprint

Metiamide
Antacids
Cimetidine
Gastritis
Stomach
Pharmaceutical Preparations
Gastric Acid
Anti-Inflammatory Agents
Tolmetin
Hemorrhage
Ketoprofen
Phenylbutazone
Histamine H2 Receptors
Naproxen
Penicillamine
Ibuprofen
Colchicine
Levodopa
Gastric Mucosa
Bile Acids and Salts

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mann, N. S. (1977). Drug induced acute erosive gastritis. Its prevention by antacid, metiamide and cimetidine. In American Journal of Proctology Gastroenterology and Colon and Rectal Surgery (2 ed., Vol. 28, pp. 23-28)

Drug induced acute erosive gastritis. Its prevention by antacid, metiamide and cimetidine. / Mann, Nirmal S.

American Journal of Proctology Gastroenterology and Colon and Rectal Surgery. Vol. 28 2. ed. 1977. p. 23-28.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mann, NS 1977, Drug induced acute erosive gastritis. Its prevention by antacid, metiamide and cimetidine. in American Journal of Proctology Gastroenterology and Colon and Rectal Surgery. 2 edn, vol. 28, pp. 23-28.
Mann NS. Drug induced acute erosive gastritis. Its prevention by antacid, metiamide and cimetidine. In American Journal of Proctology Gastroenterology and Colon and Rectal Surgery. 2 ed. Vol. 28. 1977. p. 23-28
Mann, Nirmal S. / Drug induced acute erosive gastritis. Its prevention by antacid, metiamide and cimetidine. American Journal of Proctology Gastroenterology and Colon and Rectal Surgery. Vol. 28 2. ed. 1977. pp. 23-28
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