Droperidol in the Emergency Department: Is it safe?

John R Richards, Aaron B. Schneir

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Droperidol is an antipsychotic and antiemetic drug that has been used extensively by Emergency Physicians, Psychiatrists, and Anesthesiologists worldwide since 1967. It also has been used effectively for other diverse conditions, such as treatment of headache and vertigo. As of January 2001, Droperidol was no longer available in Europe after its founder, Janssen-Cilag Pharmaceuticals, discontinued its distribution. In December 2001, the United States Food and Drug Administration (FDA) placed a black box warning on the use of Droperidol in response to an association between Droperidol and fatal cardiac dysrhythmias, such as torsade de pointes, resulting from prolongation of the QT interval. In this review we closely examine the pharmacology, indications, use, and complications associated with Droperidol, and speculate on its future use in the Emergency Department.

Original languageEnglish (US)
Pages (from-to)441-447
Number of pages7
JournalJournal of Emergency Medicine
Volume24
Issue number4
DOIs
StatePublished - May 2003

Keywords

  • Antipsychotic
  • Droperidol
  • Emergency Department
  • FDA warning
  • Inapsine

ASJC Scopus subject areas

  • Emergency Medicine

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