Droperidol in the Emergency Department: Is it safe?

John R Richards, Aaron B. Schneir

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Droperidol is an antipsychotic and antiemetic drug that has been used extensively by Emergency Physicians, Psychiatrists, and Anesthesiologists worldwide since 1967. It also has been used effectively for other diverse conditions, such as treatment of headache and vertigo. As of January 2001, Droperidol was no longer available in Europe after its founder, Janssen-Cilag Pharmaceuticals, discontinued its distribution. In December 2001, the United States Food and Drug Administration (FDA) placed a black box warning on the use of Droperidol in response to an association between Droperidol and fatal cardiac dysrhythmias, such as torsade de pointes, resulting from prolongation of the QT interval. In this review we closely examine the pharmacology, indications, use, and complications associated with Droperidol, and speculate on its future use in the Emergency Department.

Original languageEnglish (US)
Pages (from-to)441-447
Number of pages7
JournalJournal of Emergency Medicine
Volume24
Issue number4
DOIs
StatePublished - May 2003

Fingerprint

Droperidol
Hospital Emergency Service
Drug Labeling
Torsades de Pointes
Antiemetics
Vertigo
United States Food and Drug Administration
Antipsychotic Agents
Headache
Psychiatry
Cardiac Arrhythmias
Emergencies
Pharmacology
Physicians
Pharmaceutical Preparations

Keywords

  • Antipsychotic
  • Droperidol
  • Emergency Department
  • FDA warning
  • Inapsine

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Droperidol in the Emergency Department : Is it safe? / Richards, John R; Schneir, Aaron B.

In: Journal of Emergency Medicine, Vol. 24, No. 4, 05.2003, p. 441-447.

Research output: Contribution to journalArticle

Richards, John R ; Schneir, Aaron B. / Droperidol in the Emergency Department : Is it safe?. In: Journal of Emergency Medicine. 2003 ; Vol. 24, No. 4. pp. 441-447.
@article{d9c1d9dfd0304c7496f8982ba6b49e0f,
title = "Droperidol in the Emergency Department: Is it safe?",
abstract = "Droperidol is an antipsychotic and antiemetic drug that has been used extensively by Emergency Physicians, Psychiatrists, and Anesthesiologists worldwide since 1967. It also has been used effectively for other diverse conditions, such as treatment of headache and vertigo. As of January 2001, Droperidol was no longer available in Europe after its founder, Janssen-Cilag Pharmaceuticals, discontinued its distribution. In December 2001, the United States Food and Drug Administration (FDA) placed a black box warning on the use of Droperidol in response to an association between Droperidol and fatal cardiac dysrhythmias, such as torsade de pointes, resulting from prolongation of the QT interval. In this review we closely examine the pharmacology, indications, use, and complications associated with Droperidol, and speculate on its future use in the Emergency Department.",
keywords = "Antipsychotic, Droperidol, Emergency Department, FDA warning, Inapsine",
author = "Richards, {John R} and Schneir, {Aaron B.}",
year = "2003",
month = "5",
doi = "10.1016/S0736-4679(03)00044-1",
language = "English (US)",
volume = "24",
pages = "441--447",
journal = "Journal of Emergency Medicine",
issn = "0736-4679",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Droperidol in the Emergency Department

T2 - Is it safe?

AU - Richards, John R

AU - Schneir, Aaron B.

PY - 2003/5

Y1 - 2003/5

N2 - Droperidol is an antipsychotic and antiemetic drug that has been used extensively by Emergency Physicians, Psychiatrists, and Anesthesiologists worldwide since 1967. It also has been used effectively for other diverse conditions, such as treatment of headache and vertigo. As of January 2001, Droperidol was no longer available in Europe after its founder, Janssen-Cilag Pharmaceuticals, discontinued its distribution. In December 2001, the United States Food and Drug Administration (FDA) placed a black box warning on the use of Droperidol in response to an association between Droperidol and fatal cardiac dysrhythmias, such as torsade de pointes, resulting from prolongation of the QT interval. In this review we closely examine the pharmacology, indications, use, and complications associated with Droperidol, and speculate on its future use in the Emergency Department.

AB - Droperidol is an antipsychotic and antiemetic drug that has been used extensively by Emergency Physicians, Psychiatrists, and Anesthesiologists worldwide since 1967. It also has been used effectively for other diverse conditions, such as treatment of headache and vertigo. As of January 2001, Droperidol was no longer available in Europe after its founder, Janssen-Cilag Pharmaceuticals, discontinued its distribution. In December 2001, the United States Food and Drug Administration (FDA) placed a black box warning on the use of Droperidol in response to an association between Droperidol and fatal cardiac dysrhythmias, such as torsade de pointes, resulting from prolongation of the QT interval. In this review we closely examine the pharmacology, indications, use, and complications associated with Droperidol, and speculate on its future use in the Emergency Department.

KW - Antipsychotic

KW - Droperidol

KW - Emergency Department

KW - FDA warning

KW - Inapsine

UR - http://www.scopus.com/inward/record.url?scp=0038365265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038365265&partnerID=8YFLogxK

U2 - 10.1016/S0736-4679(03)00044-1

DO - 10.1016/S0736-4679(03)00044-1

M3 - Article

C2 - 12745049

AN - SCOPUS:0038365265

VL - 24

SP - 441

EP - 447

JO - Journal of Emergency Medicine

JF - Journal of Emergency Medicine

SN - 0736-4679

IS - 4

ER -