We conducted a planning study to compare Varian's RapidArc (RA) and helical TomoTherapy (HT) for the treatment of pancreatic cancer. Three intensity-modulated radiotherapy (IMRT) plans were generated for 8 patients with pancreatic cancer: one using HT with 6-MV beam (Plan_ HT6), one using single-arc RA with 6-MV beam (Plan_ RA6), and one using single-arc RA with 15-MV beam (Plan_ RA15). Dosimetric indices including high/low conformality index (CI 100%/CI 50%), heterogeneity index (HI), monitor units (MUs), and doses to organs at risk (OARs) were compared. The mean CI 100% was statistically equivalent with respect to the 2 treatment techniques, as well as beam energy (0.99, 1.01, and 1.02 for Plan_ HT6, Plan_ RA6, and Plan_ RA156, respectively). The CI 50% and HI were improved in both RA plans over the HT plan. The RA plans significantly reduced MU (MU RA6 = 697, MU RA15 = 548) compared with HT (MU HT6 = 6177, p = 0.008 in both cases). The mean maximum cord dose was decreased from 29.6 Gy in Plan_ HT6 to 21.6 Gy (p = 0.05) in Plan_ RA6 and 21.7 Gy (p = 0.04) in Plan_ RA15. The mean bowel dose decreased from 17.2 Gy in Plan_ HT6 to 15.2 Gy (p = 0.03) in Plan_ RA6 and 15.0 Gy (p = 0.03) Plan_ RA15. The mean liver dose decreased from 8.4 Gy in Plan_ HT6 to 6.3 Gy (p = 0.04) in Plan_ RA6 and 6.2 Gy in Plan_ RA15. Variations of the mean dose to the duodenum, kidneys, and stomach were statistically insignificant. RA and HT can both deliver conformal dose distributions to target volumes while limiting the dose to surrounding OARs in the treatment of pancreatic cancer. Dosimetric advantages might be gained by using RA over HT by reducing the dose to OARs and total MUs used for treatment.
- Pancreatic cancer
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology