Dose response characteristics of hypertonic saline dextran solutions

L. Halvorsen, R. A. Gunther, M. A. Dubick, James W Holcroft

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In an effort to find the best hypertonic saline-dextran solution (HSD) for prehospital use, 33 chronically catheterized sheep were bled using a fixed pressure shock model (50 mm Hg x 2 hours) and resuscitated with 4 ml/kg of HSD solution (2-minute bolus). In the first set of experiments colloid was varied and sodium chloride was held constant, as 7.5% NaCl was paired with either 0%, 6%, or 12% dextran 70. A dose-response relationship existed, with cardiac output increasing 20% with each sequential dextran 70 concentration. Mean arterial blood pressure was higher in animals that were resuscitated with either the 7.5% NaCl/6% dextran 70 or 7.5% NaCl/12% dextran 70 solution (p < 0.05). Using the optimal dextran 70 concentration from the first set of experiments (i.e., 12%), solute was varied in a second set of experiments comparing 0.9%, 3.8%, 7.5%, or 10% NaCl/12% dextran 70. Again dose-response features were demonstrated, as cardiac output increased as a function of NaCl concentration. However, this response plateaued with the 7.5% NaCl concentration and no advantage was obtained by increasing the NaCl concentration to 10%. We conclude that a 4-ml/kg bolus of 7.5% NaCl/12% dextran 70 solution may be a more effective form of therapy than those previously evaluated. This new solution is now being included in our ongoing clinical trials.

Original languageEnglish (US)
Pages (from-to)785-794
Number of pages10
JournalJournal of Trauma
Volume31
Issue number6
StatePublished - 1991

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Dextrans
Cardiac Output
Arterial Pressure
Colloids
hypertonic saline-dextran solution
Sodium Chloride
Shock
Sheep
Clinical Trials
Pressure

ASJC Scopus subject areas

  • Surgery

Cite this

Halvorsen, L., Gunther, R. A., Dubick, M. A., & Holcroft, J. W. (1991). Dose response characteristics of hypertonic saline dextran solutions. Journal of Trauma, 31(6), 785-794.

Dose response characteristics of hypertonic saline dextran solutions. / Halvorsen, L.; Gunther, R. A.; Dubick, M. A.; Holcroft, James W.

In: Journal of Trauma, Vol. 31, No. 6, 1991, p. 785-794.

Research output: Contribution to journalArticle

Halvorsen, L, Gunther, RA, Dubick, MA & Holcroft, JW 1991, 'Dose response characteristics of hypertonic saline dextran solutions', Journal of Trauma, vol. 31, no. 6, pp. 785-794.
Halvorsen, L. ; Gunther, R. A. ; Dubick, M. A. ; Holcroft, James W. / Dose response characteristics of hypertonic saline dextran solutions. In: Journal of Trauma. 1991 ; Vol. 31, No. 6. pp. 785-794.
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