Dose-dependent proconvulsant and anticonvulsant actions of the alpha2 adrenergic agonist, xylazine, on kindled seizures in the rat

Robert M. Joy, Larry G. Stark, Timothy E Albertson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effects of the alpha2 adrenergic agonist, xylazine, was evaluated on kindling acquisition and on kindled seizure expression in rats. Dose-dependent proconvulsant and anticonvulsant properties were found. The proconvulsant effects were observed at low (0.3 mg/kg) doses. In previously kindled rats these consisted of a decrease in afterdischarge threshold and an increase in the length and severity of the accompanying seizure. This dose also facilitated the rate of kindling in naive subjects. The anticonvulsant effects were observed at higher dose levels (3-20 mg/kg) which also produced sedation and ataxia. If these effects upon kindling are related to the adrenergic actions of xylazine, then it is proposed that the proconvulsant effects are associated with alpha2 receptor activation and the anticonvulsant effects with alpha1 receptor activation.

Original languageEnglish (US)
Pages (from-to)345-350
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume19
Issue number2
DOIs
StatePublished - 1983

Fingerprint

Adrenergic alpha-2 Receptor Agonists
Xylazine
Anticonvulsants
Rats
Seizures
Chemical activation
Ataxia
Adrenergic Agents

Keywords

  • Adrenergic agonist
  • Adrenergic drugs
  • Alpha adrenergic agonist
  • Amygdala
  • Experimental epilepsy
  • Kindling
  • Nervous system
  • Seizures

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

@article{ed4feb9ad7f34998b699cc50849417f6,
title = "Dose-dependent proconvulsant and anticonvulsant actions of the alpha2 adrenergic agonist, xylazine, on kindled seizures in the rat",
abstract = "The effects of the alpha2 adrenergic agonist, xylazine, was evaluated on kindling acquisition and on kindled seizure expression in rats. Dose-dependent proconvulsant and anticonvulsant properties were found. The proconvulsant effects were observed at low (0.3 mg/kg) doses. In previously kindled rats these consisted of a decrease in afterdischarge threshold and an increase in the length and severity of the accompanying seizure. This dose also facilitated the rate of kindling in naive subjects. The anticonvulsant effects were observed at higher dose levels (3-20 mg/kg) which also produced sedation and ataxia. If these effects upon kindling are related to the adrenergic actions of xylazine, then it is proposed that the proconvulsant effects are associated with alpha2 receptor activation and the anticonvulsant effects with alpha1 receptor activation.",
keywords = "Adrenergic agonist, Adrenergic drugs, Alpha adrenergic agonist, Amygdala, Experimental epilepsy, Kindling, Nervous system, Seizures",
author = "Joy, {Robert M.} and Stark, {Larry G.} and Albertson, {Timothy E}",
year = "1983",
doi = "10.1016/0091-3057(83)90063-1",
language = "English (US)",
volume = "19",
pages = "345--350",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Dose-dependent proconvulsant and anticonvulsant actions of the alpha2 adrenergic agonist, xylazine, on kindled seizures in the rat

AU - Joy, Robert M.

AU - Stark, Larry G.

AU - Albertson, Timothy E

PY - 1983

Y1 - 1983

N2 - The effects of the alpha2 adrenergic agonist, xylazine, was evaluated on kindling acquisition and on kindled seizure expression in rats. Dose-dependent proconvulsant and anticonvulsant properties were found. The proconvulsant effects were observed at low (0.3 mg/kg) doses. In previously kindled rats these consisted of a decrease in afterdischarge threshold and an increase in the length and severity of the accompanying seizure. This dose also facilitated the rate of kindling in naive subjects. The anticonvulsant effects were observed at higher dose levels (3-20 mg/kg) which also produced sedation and ataxia. If these effects upon kindling are related to the adrenergic actions of xylazine, then it is proposed that the proconvulsant effects are associated with alpha2 receptor activation and the anticonvulsant effects with alpha1 receptor activation.

AB - The effects of the alpha2 adrenergic agonist, xylazine, was evaluated on kindling acquisition and on kindled seizure expression in rats. Dose-dependent proconvulsant and anticonvulsant properties were found. The proconvulsant effects were observed at low (0.3 mg/kg) doses. In previously kindled rats these consisted of a decrease in afterdischarge threshold and an increase in the length and severity of the accompanying seizure. This dose also facilitated the rate of kindling in naive subjects. The anticonvulsant effects were observed at higher dose levels (3-20 mg/kg) which also produced sedation and ataxia. If these effects upon kindling are related to the adrenergic actions of xylazine, then it is proposed that the proconvulsant effects are associated with alpha2 receptor activation and the anticonvulsant effects with alpha1 receptor activation.

KW - Adrenergic agonist

KW - Adrenergic drugs

KW - Alpha adrenergic agonist

KW - Amygdala

KW - Experimental epilepsy

KW - Kindling

KW - Nervous system

KW - Seizures

UR - http://www.scopus.com/inward/record.url?scp=0020592423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020592423&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(83)90063-1

DO - 10.1016/0091-3057(83)90063-1

M3 - Article

C2 - 6314391

AN - SCOPUS:0020592423

VL - 19

SP - 345

EP - 350

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 2

ER -