Dose-dependent proconvulsant and anticonvulsant actions of the alpha2 adrenergic agonist, xylazine, on kindled seizures in the rat

Robert M. Joy, Larry G. Stark, Timothy E Albertson

Research output: Contribution to journalArticle

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Abstract

The effects of the alpha2 adrenergic agonist, xylazine, was evaluated on kindling acquisition and on kindled seizure expression in rats. Dose-dependent proconvulsant and anticonvulsant properties were found. The proconvulsant effects were observed at low (0.3 mg/kg) doses. In previously kindled rats these consisted of a decrease in afterdischarge threshold and an increase in the length and severity of the accompanying seizure. This dose also facilitated the rate of kindling in naive subjects. The anticonvulsant effects were observed at higher dose levels (3-20 mg/kg) which also produced sedation and ataxia. If these effects upon kindling are related to the adrenergic actions of xylazine, then it is proposed that the proconvulsant effects are associated with alpha2 receptor activation and the anticonvulsant effects with alpha1 receptor activation.

Original languageEnglish (US)
Pages (from-to)345-350
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume19
Issue number2
DOIs
StatePublished - 1983

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Keywords

  • Adrenergic agonist
  • Adrenergic drugs
  • Alpha adrenergic agonist
  • Amygdala
  • Experimental epilepsy
  • Kindling
  • Nervous system
  • Seizures

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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